Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique.

BACKGROUND: This study aimed to determine the proportion of cases with abnormal intestinal motility among patients with functional bowel disorders. To this end, we applied an original method, previously developed in our laboratory, for analysis of endoluminal images obtained by capsule endoscopy. This novel technology is based on computer vision and machine learning techniques. METHODS: The endoscopic capsule (Pillcam SB1; Given Imaging, Yokneam, Israel) was administered to 80 patients with functional bowel disorders and 70 healthy subjects. Endoluminal image analysis was performed with a computer vision program developed for the evaluation of contractile events (luminal occlusions and radial wrinkles), non-contractile patterns (open tunnel and smooth wall patterns), type of content (secretions, chyme) and motion of wall and contents. Normality range and discrimination of abnormal cases were established by a machine learning technique. Specifically, an iterative classifier (one-class support vector machine) was applied in a random population of 50 healthy subjects as a training set and the remaining subjects (20 healthy subjects and 80 patients) as a test set. KEY RESULTS: The classifier identified as abnormal 29% of patients with functional diseases of the bowel (23 of 80), and as normal 97% of healthy subjects (68 of 70) (P < 0.05 by chi-squared test). Patients identified as abnormal clustered in two groups, which exhibited either a hyper- or a hypodynamic motility pattern. The motor behavior was unrelated to clinical features. CONCLUSIONS & INFERENCES: With appropriate methodology, abnormal intestinal motility can be demonstrated in a significant proportion of patients with functional bowel disorders, implying a pathologic disturbance of gut physiology.

Intestinal motor activity, endoluminal motion and transit.

A programme for evaluation of intestinal motility has been recently developed based on endoluminal image analysis using computer vision methodology and machine learning techniques. Our aim was to determine the effect of intestinal muscle inhibition on wall motion, dynamics of luminal content and transit in the small bowel. Fourteen healthy subjects ingested the endoscopic capsule (Pillcam, Given Imaging) in fasting conditions. Seven of them received glucagon (4.8 microg kg(-1) bolus followed by a 9.6 microg kg(-1) h(-1) infusion during 1 h) and in the other seven, fasting activity was recorded, as controls. This dose of glucagon has previously shown to inhibit both tonic and phasic intestinal motor activity. Endoluminal image and displacement was analyzed by means of a computer vision programme specifically developed for the evaluation of muscular activity (contractile and non-contractile patterns), intestinal contents, endoluminal motion and transit. Thirty-minute periods before, during and after glucagon infusion were analyzed and compared with equivalent periods in controls. No differences were found in the parameters measured during the baseline (pretest) periods when comparing glucagon and control experiments. During glucagon infusion, there was a significant reduction in contractile activity (0.2 +/- 0.1 vs 4.2 +/- 0.9 luminal closures per min, P < 0.05; 0.4 +/- 0.1 vs 3.4 +/- 1.2% of images with radial wrinkles, P < 0.05) and a significant reduction of endoluminal motion (82 +/- 9 vs 21 +/- 10% of static images, P < 0.05). Endoluminal image analysis, by means of computer vision and machine learning techniques, can reliably detect reduced intestinal muscle activity and motion.

Shared feature extraction for nearest neighbor face recognition.

In this paper, we propose a new supervised linear feature extraction technique for multiclass classification problems that is specially suited to the nearest neighbor classifier (NN). The problem of finding the optimal linear projection matrix is defined as a classification problem and the Adaboost algorithm is used to compute it in an iterative way. This strategy allows the introduction of a multitask learning (MTL) criterion in the method and results in a solution that makes no assumptions about the data distribution and that is specially appropriated to solve the small sample size problem. The performance of the method is illustrated by an application to the face recognition problem. The experiments show that the representation obtained following the multitask approach improves the classic feature extraction algorithms when using the NN classifier, especially when we have a few examples from each class.

Clustering in image space for place recognition and visual annotations for human-robot interaction.

The most classical way of attempting to solve the vision-guided navigation problem for autonomous robots corresponds to the use of three-dimensional (3-D) geometrical descriptions of the scene; what is known as model-based approaches. However, these approaches do not facilitate the user's task because they require that geometrically precise models of the 3-D environment be given by the user. In this paper, we propose the use of "annotations" posted on some type of blackboard or "descriptive" map to facilitate this user-robot interaction. We show that, by using this technique, user commands can be as simple as "go to label 5." To build such a mechanism, new approaches for vision-guided mobile robot navigation have to be found. We show that this can be achieved by using mixture models within an appearance-based paradigm. Mixture models are more useful in practice than other pattern recognition methods such as principal component analysis (PCA) or Fisher discriminant analysis (FDA)-also known as linear discriminant analysis (LDA), because they can represent nonlinear subspaces. However, given the fact that mixture models are usually learned using the expectation-maximization (EM) algorithm which is a gradient ascent technique, the system cannot always converge to a desired final solution, due to the local maxima problem. To resolve this, a genetic version of the EM algorithm is used. We then show the capabilities of this latest approach on a navigation task that uses the above described "annotations."

Automated classification of renal interstitium and tubules by local texture analysis and a neural network.

OBJECTIVE: To segment renal interstitial space in order to automatically quantify renal cortical interstitial volume fraction (Vvint/cortex) by means of image analysis techniques. STUDY DESIGN: The study group consisted of 35 renal biopsies with different degrees of chronic interstitial damage. Biopsies were stained with Sirius red and digitized under polarized light. Two methods were employed to segment interstitial space: (1) interstitial bright particles were thresholded, and afterwards interstitial space was reconstructed with a morphologic operation, and (2) the texture of the surroundings of each pixel was quantified by means of local granulometry, and this information was employed as the input of a neural network in order to classify interstitial and tubular pixels. RESULTS: The correlation between Vvint/cortex obtained manually and both methods was r = .92. The first method produced some deformation of tubular contours and underestimated Vvint/cortex (beta = .70) when compared to the second approach (beta = .95) (P < .05). CONCLUSION: Two different algorithms based on image analysis techniques allow the classification of renal interstitial and tubular structures and consequently allow the automated and precise estimation of renal Vvint/cortex.

Quantification of interstitial chronic renal damage by means of texture analysis.

There is a relationship between chronic renal damage and renal function at the time of biopsy. Since the quantification of interstitial lesions with morphometric techniques is very time consuming, a fully automatic method to quantify chronic damage is desirable. Progression of chronic renal damage could be viewed as a texture modification of tubulointerstitial structures. The aim of the present work is to study whether chronic renal damage could be automatically measured by means of texture analysis based on mathematical morphology. Among the morphological tools the best suited for our purpose is that of granulometry. Between four and six fields from 35 renal biopsies with different degrees of renal damage were stained with Sirius red and digitized under polarized light. In each field granulometric function with a circular structuring element was obtained. Interstitial volume fraction was measured with a point counting technique. Glomerular filtration rate at the time of biopsy was available in each case. A positive relationship between granulometric function and glomerular filtration rate was observed (r2 = 0.85). The determination coefficient between interstitial volume fraction and renal function was (r2 = 0.54). In conclusion, we describe a fully automatic method that precisely quantifies interstitial chronic renal damage.