[The Relationship Between Level of End-Products of Tissue Glycation and Pulse Wave Velocity in Non-diabetic Patients With Cardiovascular Disease].

AIM: of the study was to assess the relationship between advanced glycation end-products measured by skin autofluorescence (AGEs) and pulse wave velocity (PWV) in non-diabetic patients with cardiovascular disease (CVD). MATERIAL AND METHODS: Skin autofluorescence (AGE--reader, DiagnOptic) and PWV in humero-malleolar segment (PWVhm) were measured in 93 non-diabetic CVD patients (mean age 63.5 years): 28 with ischemic heart disease (IHD) and 65 without IHD from the group with moderate/high risk of development of cardiovascular complications. RESULTS: Significant positive association was observed between AGEs and PWVhm (r = 0.31, p = 0.003). This correlation was found only in patients without IHD (r = 0.44, p < 0.0003). Positive association AGEs with of age (r = 0.52, p = 0.006) was observed irrespective of IHD. AGEs was not the significant determinant of PWVhm in multiple regression analysis. CONCLUSION: Relationship between AGEs and PWVhm was found in non-diabetic moderate/high-risk patients. In contrast to age and systolic blood pressure AGEs was not the significant determinant of PWVhm.

[Using meldonium to improve the adaptation of patients with cardiovascular disease to the effects of heat and correction of associated oxidative stress].

Given that prolonged exposure to extreme climatic situations may play a role independent of stress factors, influencing the course of the underlying disease, the authors considered appropriate assessment of the effectiveness of additional prophylactic administration of drugs that increase the body's resistance to stress (adaptogens). The purpose of the study - to evaluate the effect of oxidative stress on meldonium, hemodynamics and quality of life of patients with cardiovascular disease (CVD) in extreme climatic conditions (summer heat). The study included 56 patients with CVD aged 38-75 years. Patients were randomized into two groups: active management (M), which in addition to basic therapy during 3 summer months received meldonium (500 mg/day), and control. The following parameters were measured: office blood pressure (BP), blood plasma malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD) activity, level of oxidized low-density lipoprotein. MDA/SOD ratio was calculated. Visual analogue scale was used for assessment of quality of life. Meldonium treated patients demonstrated marked reduction of systolic BP and heart rate during heat, increased sodium level at the 2nd visit, improved quality of life. These changes corresponded to adaptive responses of healthy men. No significant dynamics of these parameters occurred in control group. MDA level during heat increased in both groups (p<0.05) but MDA/SOD ratio, which characterizes the "oxidation potential" of blood, increased significantly during the summer heat only in the control group. Meldonium can be used as an adaptogen in CVD patients during the summer heat.

[The ability to use meldonium as adaptogen in winter in patients with cardiovascular disease].

Given that the effects of frost can play the role of independent stress factor influencing the course of cardiovascular disease (CVD), it is reasonable to supplementation of drugs that increase the body's resistance to cold stress. Aim: To evaluate the possibility of using meldonium to prevent unwanted seasonal changes in CVD patients in the winter. The study included 49 patients with CVD aged 38-75 years. Patients were randomized into 2 groups: active management (M), in which in addition to the basic therapy received during the winter 3 months meldonium 1000 mg/day, and a control (K). We measured office blood pressure, heart rate, blood chemistry, determination of glycosylation end products (DGP). Filled with a visual analogue scale (VAS) to assess the quality of life (QOL). During frost marked increase in blood glucose (p = 0.02) in group K, persisting throughout the winter, and an increase in tissue DGP in March (p = 0.002). In group M glucose and DGP not significantly raised. In group M at the peak of cold showed a reduction in cholesterol levels. Admission meldonium associated with improved quality of life, in the dynamics of the group K was negative [Δ +10.0 VAS scores in group M versus -7.5 points in the group K in the cold (p = 0.04) and Δ +10,0 points vs -5.0 points, respectively, in March 2014 (p = 0.055)]. Adding to the basic treatment of patients with CVD meldonium in a dose of 1000 mg/day in winter, accompanied by improved quality of life, as well as let negative changes in carbohydrate metabolism.

[Effects of exercise on markers of hemostatic activation in young survivors of myocardial infarction]. / Vliianie fizicheskoi nagruzki na markery aktivatsii sistemy hemostaza u bol'nykh, perenesshikh infarkt miokarda v molodom vozraste.

AIM: To study the effect of exercise on markers of endothelial impairment, platelet activation, thrombin formation, fibrinolysis in patients who survived myocardial infarction (MI) at young age. MATERIAL AND METHODS: The levels of fibrinogen (F), Willebrand factor (WF), beta-thromboglobulin (BTG), fragment 1+2 of prothrombin activation (F 1+2), antigen of tissue plasminogen activator (TPA), D-dimer at rest as well as betaTG, F 1+2, WF, TPA antigen and its activity in treadmill test (TT) were compared in 25 patients younger than 35 years who survived Q-myocardial infarction (Q-MI) > 6 months before (group 1), 10 of whom had unaffected or little affected coronary arteries as shown by coronaroangiography (subgroup 1H) while 15 had stenosing coronary atherosclerosis (subgroup 1A); in 20 patients who had Q-MI at the age of 40-55 years (group 2); in 10 healthy patients under 35 years of age (group 3). RESULTS: Initial concentrations of F, F 1+2 and TPA antigen were significantly higher than in healthy subjects. F and TPA antigen were higher in subgroup 1A than in subgroup 1H. D-dimer was higher in group 2 vs 1. TT raised concentration of BTG in all the groups, induced a stable trend of F 1+2 rise in patients of subgroup 1H (p = 0.059), raised WF only in group 3, TPA antigen at peak stress in all the patients being in group 1 higher than in healthy controls and in subgroup 1A than in subgroup 1H. TPA antigen was more active at the peak stress in group 1 than in group 2 but the differences became insignificant in analyzing only patients who reached submaximal load by heart rate. CONCLUSION: Stenosing coronary atherosclerosis in patients after MI at young age is associated with high F and TPA levels. Elevated F 1+2 was registered at exercise test in young patients free of coronary obstruction. TPA levels were raised higher by exercise in patients with stenosing atherosclerosis of the coronary arteries. TPA activity induced by exercise depended more on exercise intensity than on the age of the patients.