1.
Biochimie
; 85(9): 863-71, 2003 Sep.
Article
in English
| MEDLINE
| ID: mdl-14652175
ABSTRACT
Using precise examples, this paper shows that carbon 13 NMR spectroscopy in conjunction with radioactive and enzymatic methods as well as with adequate mathematical modeling of metabolic pathways allows not only to identify but also to quantify fluxes through enzymes involved in substrate and drug metabolism. Carbon 13 NMR spectroscopy is a tool of unprecedented power to unravel the complexity of renal metabolism. Currently it plays a major role in what is nowadays called metabolomics.
Subject(s)
Energy Metabolism , Glucose/metabolism , Glutamic Acid/metabolism , Kidney Tubules, Proximal/metabolism , Nuclear Magnetic Resonance, Biomolecular , Animals , Carbon Isotopes , Lactates/metabolism , Pyruvate Carboxylase/metabolism , Pyruvate Dehydrogenase Complex/metabolism , Rabbits
2.
Eur J Pediatr
; 146 Suppl 1: A32-7, 1987.
Article
in English
| MEDLINE
| ID: mdl-3691575
Subject(s)
Phenylalanine/blood , Phenylketonurias/diet therapy , Trace Elements/blood , Child , Child, Preschool , Female , Ferritins/blood , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Nutritional Status , Phenylalanine/administration & dosage , Phenylketonurias/blood , Time Factors
3.
Minerva Pediatr
; 36(13-14): 707-12, 1984 Jul 31.
Article
in Italian
| MEDLINE
| ID: mdl-6095004
