99mTc-MIBI scintimammography using a dedicated nuclear mammograph.

UNLABELLED: This study reports on a prototype single-photon emission mammograph (SPEM) dedicated to 99mTc-hexakis-2-methoxyisobutile isonitrile (MIBI) scintimammography. Main technical features are reported together with physical performance. Preliminary patient data are also reported. METHODS: The SPEM detector head is composed of a CsI(T1) scintillating array coupled to a Hamamatsu R3292 position-sensitive photomultiplier tube with crossed-wire anode. The high-resolution collimator is 35-mm thick with a 1.7-mm hole diameter and a 0.2-mm septal thickness. The electronic acquisition system is composed of five integrated cards with computation based on high-speed programmable microprocessors. The readout electronics include correction maps for on-line energy correction and spatial uniformity. The small size of the detector head allows the use of mechanical breast compression to minimize detection distance and tissue scatter. After physical SPEM performance evaluation in vivo scintimammography was performed in 29 patients and was compared with a state-of-the-art Anger camera. RESULTS: The SPEM showed an intrinsic spatial resolution of 2 mm, an energy resolution of 23% FWHM at 122 keV and spatial uniformities of 18% (integral) and 13.5% (differential). The SPEM imaged one 0.4-cm carcinoma missed by the Anger camera and resolved as separate lumps an irregular focal uptake on the Anger camera image. The remaining cases yielded concordant results. CONCLUSION: The SPEM prototype presented in this study shows adequate physical characteristics for 99mTc-MIBI scintimammography.

[Tuberculosis lupus after BCG vaccination. A rare complication of the vaccination]. / Le lupus tuberculeux post-BCG. Une complication rare de la vaccination.

BACKGROUND: Cutaneous reactions to BCG have rarely been a problem and BCG is one of the safest vaccines in use. CASE REPORT: Two children, 6 and 7 years old, developed local tuberculosis lupus 7 and 8 months, respectively, after BCG vaccination. Cutaneous changes cured after a treatment with isoniazid for 9 months in one case with observance of the treatment was uncertain in the other. CONCLUSION: Tuberculosis lupus is a rare complication of BCG vaccination. Its clinical features are identical to those of the vulgaris lupus. The diagnosis is based on clinical, pathology aspects and anamnesia. This complication should not be a contra-indication of BCG immunization.

[Cutaneous manifestations in trisomy 21]. / Les manifestations cutanées de la trisomie 21

The possibility of cutaneous manifestations in Down's syndromes not a surprise because we known that this affection affects the three embryonic parts. This cutaneous disorder is described by many authors but it is variable and not specific. The authors had occasion to see four cases of alopecia areata in mongolian children. They do an analytic study of variable manifestations. They insist on frequency of hyperkeratotic lesions, alopecia areata, alterations of vasomotricity and elastic dystrophies. In the group of chromosomic aberrations, down's syndrome is alone where the cutaneous manifestations are studied because the patients have a good survival.