ABSTRACT
This is a multicenter cross-sectional study where we aimed to detect the rate of osteopenia/osteoporosis in an HIV female population (WLWHIV) by means of "heel quantitative ultrasound" (QUS) measurement. We enrolled 273 patients, mean age 48.1 years, 36% menopausal, 96% on combination antiretroviral therapy (cART). Calcaneal measure of bone mass index by QUS revealed osteopenia and osteoporosis in 76 (27.8%) and 16 (5.9%) WLWHIV. Our data underline the correlation between low QUS parameters and traditional risk factors for osteoporosis rather than with cART exposure, thus suggesting the crucial importance of detection and correction of traditional risk factors for osteoporosis in WLWHIV.
Subject(s)
Bone Diseases, Metabolic/diagnostic imaging , Calcaneus/diagnostic imaging , HIV Infections/diagnostic imaging , Osteoporosis/diagnostic imaging , Ultrasonography/methods , Aged , Bone Density , Bone Diseases, Metabolic/epidemiology , Bone Diseases, Metabolic/virology , Cross-Sectional Studies , Female , HIV , HIV Infections/complications , Humans , Italy/epidemiology , Middle Aged , Osteoporosis/epidemiology , Osteoporosis/virology , Risk FactorsABSTRACT
We report pharmacokinetic data on two gastrectomized, patients affected by tuberculosis. Drugs plasmatic concentrations were measured after seven days of oral therapy by a validated high performance liquid chromatography-mass spectrometry (HPLC-MS) method and the area under the concentration-time-curve (AUC) over 24 hours (AUC(0-24)) was calculated. A sub-therapeutic level of isoniazid was found in a patient with total gastrectomy with a C(max) of 0,395 mg\L and AUC(0-24) level of 4.75 hr*mg/L. The level of the other antitubercular drugs was adequate. These findings support the need to monitor anti tubercular drug levels to facilitate early detection of therapeutic failure, above all in patients treated with isoniazid and with potential problems on oral drugs absorption.
