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1.
AJNR Am J Neuroradiol ; 41(10): 1786-1790, 2020 10.
Article in English | MEDLINE | ID: mdl-32819895

ABSTRACT

Chordomas are rare primary bone malignancies derived from notochord remnants. The tumors often are slow-growing and often present with indolent, nonspecific symptoms. Nevertheless, chordomas are locally aggressive and highly prone to local recurrence, necessitating precise planning before biopsy and/or surgical resection. Familiarity with the imaging features of chordomas is, therefore, essential. This case highlights the typical imaging and pathologic features of a spinal chordoma as well as the surgical approach and the patient's subsequent outcome.


Subject(s)
Chordoma/pathology , Spinal Neoplasms/pathology , Aged , Back Pain/etiology , Chordoma/complications , Chordoma/surgery , Humans , Lumbar Vertebrae/pathology , Male , Neoplasm Recurrence, Local/pathology , Spinal Neoplasms/complications , Spinal Neoplasms/surgery , Vertebral Body/pathology
2.
An Esp Pediatr ; 56(4): 298-303, 2002 Apr.
Article in Spanish | MEDLINE | ID: mdl-11927096

ABSTRACT

BACKGROUND: Conclusive data on the risk factors that modify bronchial hyperresponsiveness after airway exposure to modulating triggers (histamine, methacholine and exercise) are lacking. In recent years some risk factors such as air pollution or infection have been questioned and even considered protective. OBJECTIVES: To assess the prevalence of bronchial hyperresponsiveness to exercise among schoolchildren and its association with different risk factors. METHODS: Three thousand thirty-three schoolchildren aged 13-14 years were studied. Participants answered a questionnaire on respiratory symptoms. A total of 2,842 children underwent exercise challenge testing for bronchial hyperresponsiveness. This study was part of the International Study of Asthma and Allergies in Childhood (ISAAC). RESULTS: A fall in peak expiratory flow rate of (15 % after exercise was found in 324 children (11.4 %), of whom 29 (9 %) also presented symptoms of asthma. Bronchial hyperresponsiveness to exercise was significantly associated with lower age, female sex, high socioeconomic level and attending a private school. No association was found between bronchial hyperresponsiveness and obesity, tobacco or viral infections. CONCLUSIONS: These findings are not completely consistent with those of other studies, suggesting that local environmental factors may influence the prevalence of bronchial hyperresponsiveness. Further studies are required to clarify these conflicting data.


Subject(s)
Asthma, Exercise-Induced/epidemiology , Asthma, Exercise-Induced/physiopathology , Bronchial Hyperreactivity , Adolescent , Age Factors , Female , Humans , Male , Peak Expiratory Flow Rate , Prevalence , Risk Factors , Schools , Sex Factors , Socioeconomic Factors , Spain/epidemiology , Surveys and Questionnaires
3.
An. esp. pediatr. (Ed. impr) ; 56(4): 298-303, abr. 2002.
Article in Es | IBECS | ID: ibc-6700

ABSTRACT

Antecedentes: No hay datos concluyentes sobre los factores de riesgo que modifican de alguna forma la hiperreactividad bronquial después de haber expuesto la vía respiratoria a un factor modulador, como histamina, metacolina o ejercicio. Algunos factores como la contaminación ambiental o las propias infecciones, en determinadas circunstancias, podrían ser factores protectores más que de riesgo para desarrollar hiperreactividad bronquial. Objetivos: Determinar la prevalencia de la hiperreactividad bronquial inducida por el ejercicio en niños de edad escolar y su asociación con diferentes factores de riesgo. Métodos: Se estudiaron 3.033 niños de 13 a 14 años de edad. Los participantes respondieron a un cuestionario sobre síntomas respiratorios y un total de 2.842 niños realizaron una prueba de reactividad bronquial al ejercicio. Este estudio forma parte del Estudio Internacional de Asma y Alergia en la Infancia (ISAAC).Resultados: En 324 niños (11,4%) se observó un descenso del flujo espiratorio máximo mayor o igual al 15%después del ejercicio y 29 (9%) presentaron síntomas clínicos de asma. La hiperreactividad bronquial se asoció de manera significativa con menor edad, sexo femenino, nivel socioeconómico más alto y asistir a una escuela privada. No se observó asociación entre hiperreactividad bronquial y obesidad, tabaco e infecciones virales. Conclusiones: Estos hallazgos no son totalmente consistentes con otros estudios, lo que hace pensar que existen factores locales medioambientales que pueden influir en la prevalencia de hiperreactividad bronquial y serían necesarios más estudios para clarificar estas contradicciones (AU)


Subject(s)
Adolescent , Male , Female , Humans , Bronchial Hyperreactivity , Spain , Socioeconomic Factors , Risk Factors , Sex Factors , Prevalence , Surveys and Questionnaires , Asthma, Exercise-Induced , Age Factors , Schools , Peak Expiratory Flow Rate
5.
Sangre (Barc) ; 34(5): 329-31, 1989 Oct.
Article in Spanish | MEDLINE | ID: mdl-2617382

ABSTRACT

Twenty-nine cases of acute promyelocytic leukaemia of children and adults are reported. This figure represents 13.61% of all the acute leukaemias and 27.88% of the acute non-lymphoblastic leukaemias found in Zulia State between 1982 and 1987. Those findings mean a higher frequency than reported in other childhood as well as adult series. So, Zulia State appears as an important geographic area for the occurrence of this type of leukaemia.


Subject(s)
Leukemia, Promyelocytic, Acute/epidemiology , Child , Child, Preschool , Cluster Analysis , Cohort Studies , Cross-Sectional Studies , Female , Humans , Male , Venezuela/epidemiology
6.
Transfusion ; 27(6): 488-90, 1987.
Article in English | MEDLINE | ID: mdl-3686659

ABSTRACT

To determine the characteristics of blood donors in western Venezuela, we collected data from 1983 to 1985 on 31,320 volunteer donors at the Blood Bank of the State of Zulia in Maracaibo. Fifty-nine percent of the donors were blood group O, 30 percent were group A, 9 percent were group B, and 2 percent were group AB. Most of the donors (93%) were Rh positive. One percent of donors had positive reactions to hepatitis B surface antigen, 3.15 percent for syphilis, 1.43 percent for antibodies to Trypanosoma cruzi, and 0.32 percent to human immunodeficiency virus antibodies. About one-half of the donors were between 18 and 30 years old, and only 10 percent were women. To determine if iron deficiency anemia was a cause for the small size of the female donor pool, we measured serum ferritin in 50 first-time female donors. Ten of these (20%) had serum ferritin values below normal, and the distribution of serum ferritin levels of all 50 was very similar to that reported for frequent donors in Europe and the United States, with a clustering of ferritin values between 10 and 70 ng per ml. The data indicate that blood donors in western Venezuela are markedly different from those in the United States and that iron supplementation may be indicated for female Venezuelan donors.


Subject(s)
Blood Donors , Adolescent , Adult , Female , Ferritins/blood , Humans , Iron Deficiencies , Male , Middle Aged , Sickle Cell Trait/diagnosis , Venezuela
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