ABSTRACT
Usando o teste de toxidez e protecao em camundongos, doze lotes de vacina antipertussis foram inativadas utilizando o metodo classico e o metodo por radiacao ionizante gama, obtida a partir do cobalto 60 de fonte radioativa J.S 7.400, Atomic Energy of Canada Limited, e conservadas em camara fria a 2oC a 8oC por tres meses. No grupo submetido a radiacao houve inativacao de bacterias, porem nao se obteve destoxificacao imediata. A imunogenicidade da vacina nao foi alterada pela radiacao, tendo a atividade protetora ocorrido semelhantemente nos dois metodos
Subject(s)
Animals , Mice , Gamma Rays , Pertussis VaccineABSTRACT
Ninety-six patients treated with irradiation for epidermoid carcinoma of the uterine cervix were evaluated for the occurrence of subcutaneous tissue fibrosis of the hypogastrium. They were retrospectively stratified according to time, dose and fractionation (TDF) factors of the subcutaneous tissue, total dose delivered and treatment techniques. In our study only the TDF value of the subcutaneous tissue was unequivocally related to the occurrence of fibrosis. The numerical value of the TDF was found to be 110, above which 88.2% of the patients displayed fibrosis.
Subject(s)
Carcinoma, Squamous Cell/radiotherapy , Radiation Injuries/etiology , Uterine Cervical Neoplasms/radiotherapy , Abdomen , Female , Humans , Pelvis , Radiotherapy Dosage , Time FactorsSubject(s)
Embryo, Mammalian/radiation effects , Gonads/radiation effects , Abnormalities, Radiation-Induced , Animals , Dose-Response Relationship, Radiation , Female , Fetus/radiation effects , Humans , Mice , Mutation/radiation effects , Neoplasms, Radiation-Induced , Pregnancy , Rats , X-Rays/adverse effectsABSTRACT
The authors studied the effect of ionizing radiation on hemaglutinating and mitogenic activity of phytohemaglutinis (PHA) in solution. 10 Krad (electron beam) are needed for the destruction of 50% of the aglutinating capacity. The mitogenic effect is more resistent to irradiation (70 Krad for 50% inactivation) maybe because both effects are due to different molecules. Changes were also followed by electrophoresis in polyacrylamida. The resistence to irradiation showed to be exponential function of the concentration of PHA in solution.
