ABSTRACT
OBJECTIVE: To study the efficacy and safety of sequential therapy with Mexidol (500 mg 1 time/day for 14 days intravenously) and Mexidol FORTE 250 (Mexidol FORTE 250 for 250 mg 3 times/day, 60 days) in patients with chronic cerebral ischemia (CCI) on an outpatient basis. MATERIAL AND METHODS: The open comparative study included 56 patients aged 46-74 years, age - 60.5+7.9 years. In all patients, the diagnosis of CCI was confirmed by clinical and neuroimaging methods. Patients of group 1 (n=28) received basic therapy and Mexidol, group 2 (n=28) received only basic therapy. RESULTS: Against the background of therapy in patients of group 1, there was a statistically significant improvement in the state of cognitive functions, a decrease in the severity of symptoms of depression and anxiety, manifestations of asthenia. The treatment was characterized by good tolerability, absence of adverse events and cases of drug interactions. CONCLUSION: Sequential therapy with Mexidol and Mexidol FORTE 250 drugs provides relief of the main clinical manifestations of CCI, is characterized by good tolerability and safety.
Subject(s)
Brain Ischemia , Outpatients , Humans , Brain Ischemia/complications , Brain Ischemia/drug therapy , Picolines , Comorbidity , Cognition , AnxietyABSTRACT
Brain dysfunctions develop in brain injuries. Drug therapy is aimed at restitution processes which are often insufficient for recovery of impaired functions. Activation of the compensatory mechanisms of damaged and intact hemispheres will modify the time and qualitative characteristics of the restitution period. With this aim in view, transcranial electromagnetic stimulation in physiological range of efferent pathways and audiovisual stimulation of afferent pathways are recommended.
Subject(s)
Central Nervous System Diseases/rehabilitation , Afferent Pathways , Central Nervous System Diseases/physiopathology , Efferent Pathways , Electromagnetic Fields , Functional Laterality , Humans , Magnetics , Motor Neurons , Physical StimulationABSTRACT
The aim of the study was to examine changes in vasodilatory endothelial function in early cerebrovascular disease of atherosclerotic genesis. All the examinees underwent ultrasonic investigation, test for reactive hyperemia of the brachial artery to evaluate vasodilatory function of the endothelium. Disturbances in the flow-dependent vasodilation were detected at initial stages of the disease, aggravated with the progress of cerebrovascular disease and therefore could serve the earliest, objective indicator of atherosclerotic process.
