ABSTRACT
The aim of this study was to examine if cessation of smoking after surgical excision of oral potentially malignant lesions in smokers reduced the risk of recurrences, development of new lesions or malignancies. 51 patients with oral leukoplakia or erythroplakia were included. They were daily smokers at the time of diagnosis and were treated surgically. Patients were advised to quit smoking at each visit. The change of smoking habits and occurrence of unfavorable events were noted during follow-up. Descriptive statistics, Fischer's exact test, Kaplan-Meier curves with log-rank test, and Cox proportional hazards model were used for analysis. 16 patients (31%) quit smoking during the observation period. Only one quitter (6%) developed recurrence compared with 11 continuing smokers (33%) (p<0.05). There were no new lesions and no malignancies among quitters compared with 8 new lesions (p<0.05) and 5 carcinomas (p>0.05) in continuing smokers. Multivariate analysis showed continuing smoking to be the most significant factor for occurrence of unfavorable events, OR 23.7. In conclusion, cessation of smoking significantly reduced the risk of unfavorable events after surgical treatment of oral potentially malignant lesions in smokers.
Subject(s)
Leukoplakia, Oral/surgery , Mouth Neoplasms/surgery , Neoplasm Recurrence, Local/prevention & control , Precancerous Conditions/surgery , Smoking Cessation , Adult , Aged , Aged, 80 and over , Erythroplasia/surgery , Female , Humans , Kaplan-Meier Estimate , Male , Middle Aged , Postoperative Period , Proportional Hazards Models , Prospective Studies , RiskSubject(s)
Facial Neoplasms/complications , Laryngeal Neoplasms/complications , Maxillary Neoplasms/complications , Mental Disorders/etiology , Adult , Aged , Autonomic Nervous System/physiopathology , Facial Neoplasms/psychology , Facial Neoplasms/surgery , Female , Humans , Laryngeal Neoplasms/psychology , Laryngectomy/psychology , Male , Maxillary Neoplasms/psychology , Maxillary Neoplasms/surgery , Mental Disorders/psychology , Middle Aged , Mood Disorders/etiology , Mood Disorders/psychology , Psychiatric Status Rating ScalesSubject(s)
Laryngeal Neoplasms/psychology , Maxillary Neoplasms/psychology , Mental Disorders/etiology , Adult , Aged , Humans , Laryngeal Neoplasms/surgery , Male , Maxillary Neoplasms/surgery , Mental Disorders/diagnosis , Mental Disorders/psychology , Middle Aged , Postoperative Period , Severity of Illness IndexABSTRACT
The study of psychological dynamics involved in malignancies of the maxillofacial area and larynx included 38 male patients (tumors in maxillofacial area--26; neoplasia of larynx--12). Patients were given different regimens of radiation and radiotherapy; 11 were operated on. Psycho-disorders induced by tumor disease and admission to cancer ward were reported in 35 (92%). With time, such disorders were progressively overshadowed by somato-psychic changes, with asthenic syndrome prevailing, and subsequently psychopath-like features developed. Psycho-organic syndrome was registered in 16 patients as they were approaching terminal stage.
