ABSTRACT
The authors considered 3 variants of radiation therapy of esophageal cancer using megavoltage radiation sources: standard methods including a continuous course, optimized planning including a continuous and split irradiation course. In the use of megavoltage sources and a continuous irradiation course the 5-year survival was 8.8%. The use of a split course in rational dosimetric planning made it possible to improve the 3-year survival up to 22.4% in a split course and up to 11.2% in a continuous course. The use of the optimum dosimetric planning made it possible while irradiationg esophageal cancer patients to reduce radiation exposure of the pulmonary tissue and to achieve a decrease of severe forms of radiation pneumonia.
Subject(s)
Esophageal Neoplasms/radiotherapy , Female , Humans , Male , Middle Aged , Pneumonia/etiology , Prognosis , Radiotherapy Dosage , Radiotherapy, High-Energy/adverse effects , Radiotherapy, High-Energy/methodsABSTRACT
The study was concerned with morphologic examination of resected esophagi from patients operated on for esophageal cancer at various intervals after radiotherapy with a total dose of 40-50 Gy. A correlation was established between the level of tumor destruction and duration of the interval between the said procedures of treatment. The results of the study suggest that the above interval should be as short as possible.
Subject(s)
Carcinoma, Squamous Cell/radiotherapy , Esophageal Neoplasms/radiotherapy , Adult , Aged , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Combined Modality Therapy , Esophageal Neoplasms/pathology , Esophageal Neoplasms/surgery , Female , Humans , Male , Middle Aged , Radiation Tolerance , Time FactorsABSTRACT
A comparative estimation is given of the results of radiotherapy in 85 patients with cancer of the true vocal cords in stage T1--2N0M0 depending on focal dosage in rad and ret units. There was noted a distinct correlation between the results of the treatment and the dosage applied. The immediate clinical cure was gained in 88.2% of cases. In this group of patients an average focal dosage corresponded to 6448 +/- 72.8 rad and 1793 +/- 22.7 ret, whereas in unsuccessful radiotherapy these were 5963 +/- 158 rad and 1675 +/- 28.3 ret. A five-year cure was noted with an average dosage of 6525 +/- 87.0 rad and 1830 +/- 52.1 ret. In a group of patients with recurrences these doses were 6390 +/- 183.4 rad and 1720 +/- 34.4 ret accordingly.
