ABSTRACT
The effects of aprotinin (2 x 10(6) and 4 x 10(6) PIU Iniprol) on the activated clotting time (ACT) with both celite- and kaolin-activated tubes were investigated in 52 patients, scheduled for elective coronary artery bypass grafting. Two whole blood samples (2 ml sample volume) were tested simultaneously with Hemochron automated timing systems at different intervals before, during and after cardiopulmonary bypass. At none of the times of measurement there was a difference in ACT measured with celite or with kaolin as coagulation activator. It is concluded that when aprotinin is used in this low dose regimen, celite- and kaolin-activated tubes are equally reliable for monitoring ACT.
Subject(s)
Aprotinin/pharmacology , Blood Coagulation/drug effects , Coronary Artery Bypass , Diatomaceous Earth/pharmacology , Dose-Response Relationship, Drug , Female , Humans , Kaolin/pharmacology , Male , Whole Blood Coagulation TimeABSTRACT
Effects of two different forms of aprotinin on postoperative blood loss and need for blood replacement were compared in patients undergoing cardiac surgery. One group (n = 46) received 2.10(6) KIA aprotinin (Trasylol), the other group (n = 46) received 2.10(6) PIU aprotinin (Iniprol). Blood loss during the first 12 hours postoperatively was similar (704 +/- 59 ml and 701 +/- 93 ml respectively). Amount of postoperatively transfused blood, fresh frozen plasma, platelets, plasma expanders and fluids was comparable in both groups. Effects of cardiopulmonary bypass on aPTT, PTT, fibrinogen and platelet count were also similar.
