ABSTRACT
Biochemical reactions of the liquor were investigated in 68 patients with gunshot wounds of the skull and brain and in closed treatment of the brain wound. The reactivity of biochemical system plays a certain role in the development of infectious complications. In dead people the developing pathogenetical biochemical syndromes having a sanogenic role of clearance from antigens of the injured tissues turn pathogenesis into thanatogenesis.
Subject(s)
Brain Concussion/cerebrospinal fluid , Skull Fractures/cerebrospinal fluid , Wounds, Gunshot/cerebrospinal fluid , Afghanistan , Brain Concussion/surgery , Humans , Military Personnel , Skull Fractures/surgery , Time Factors , Treatment Outcome , USSR , Warfare , Wounds, Gunshot/surgeryABSTRACT
The specific features of immunological responses and enzymatic activity of cerebrospinal fluid in the development of intracranial infectious complications were outlined in 16 neurosurgical patients after surgical interventions. On days 1-3-5 days after surgery, the immunobiochemical spectrum of cerebrospinal fluid showed substantial changes associated with the impaired permeability of the blood-brain barrier and the stress-induced transition of biochemical functional systems on the minimum functioning during anaerobic energy supply. Increasing lipid peroxidation processes reflect the result of catabolic reactions and energy deficiency, followed by intensive cytolysis of leukocytes and nerve cells. With this, antibody synthesis and great rises in the formation of circulating immune complexes is the essence of sanogenetic mechanisms basically aimed at eliminating the released and bound antigen in the given time interval.
Subject(s)
Meningitis/cerebrospinal fluid , Meningoencephalitis/cerebrospinal fluid , Postoperative Complications/cerebrospinal fluid , Antibody Formation , Antigen-Antibody Complex/cerebrospinal fluid , Cerebrospinal Fluid/enzymology , Cerebrospinal Fluid/immunology , Clinical Enzyme Tests , Humans , Lipid Peroxidation , Meningitis/diagnosis , Meningoencephalitis/diagnosis , Postoperative Complications/diagnosis , Time FactorsABSTRACT
A system of individual immunotherapy is proposed which is based on the selection of an immunomodulator maximally suitable for the patients' immune system which is the therapeutic measure directed to the stimulation of forming the functional adaptive CNS dominant adequate to the pathological focus--the main component of sanogenesis in neuroanimatologic patients representing a complex of psychoneuroimmunoendocrine connections of the organism. As a result of immunotherapy the adequate adaptive CNS dominant makes concrete effector adaptive functional systems, determines the rate and sequence of the course of the adaptive reactions.
Subject(s)
Immunotherapy/methods , Meningitis/therapy , Meningoencephalitis/therapy , Postoperative Care/methods , Postoperative Complications/therapy , Combined Modality Therapy , Humans , Immunity, Cellular , Meningitis/immunology , Meningoencephalitis/immunology , Postoperative Complications/immunologyABSTRACT
The influence of the individual immunotherapy with the selection of the immunomodulator upon the level of lymphocyte functional activity on sanogenetic mechanisms of local immune system of the cerebrospinal liquid was investigated. It is shown, that sanogenetic potential of the CSF local immune system is mediated by the presence of sufficient adaptive resources, maintaining protective immunobiochemical processes in the active state for the whole period of adaptation to injury. Individual immunotherapy promotes optimization of the sanogenetic mechanisms in the cerebral local immunity system on postoperative period in complicated craniocerebral injury.
Subject(s)
Brain Injuries/cerebrospinal fluid , Brain Injuries/therapy , Immunotherapy/methods , Surgical Wound Infection/cerebrospinal fluid , Surgical Wound Infection/therapy , Anti-Bacterial Agents/therapeutic use , Antibody Formation , Cerebrospinal Fluid/enzymology , Cerebrospinal Fluid/immunology , Combined Modality Therapy , Humans , Time FactorsABSTRACT
The data of clinical neuroimmunology permit to separate some immunological syndromes in the course and in the outcome of the injured brain disease. In cerebral concussion these are to be a stressing immune deficiency and reversible neurosensibilization; lightly grave contusions is followed by the syndrome of immunobarrier function disturbance; in moderately grave or grave contusions--border-line immunodysfunction; the dead showed unfolding of the neurogenic immunodysfunction syndrome, worsened by immunologic paralysis.
Subject(s)
Antigen-Antibody Reactions , Brain Injuries/immunology , Wounds, Nonpenetrating/immunology , Adolescent , Adult , Antibody Formation , Brain Concussion/immunology , Child, Preschool , Female , Humans , Immunity, Cellular , Immunity, Innate , Male , Middle Aged , Neuroimmunomodulation , Time FactorsABSTRACT
The paper shows the formation of immunopathological syndromes in the cerebrospinal fluid in the victims with gunshot wounds in relation to the policy and outcome of treatment. Suturing the dura mater during a primary surgical treatment should be regarded as a protective process to limit antigen release, the development of immunological paralysis and autoimmunization. Deaths are caused by the neurogenic immune dysfunction induced by the inadequate functioning of the psychoneuroimmunoendocrine connections of the whole body.
