ABSTRACT
Chronic experiments on stray dogs with modeling peritonitis showed that a complex therapy involving etoxidol favors improvement of the electrophysiological and metabolic heart activity and provides correction of the lipid distress syndrome. It is established that the lipid regulating effect of etoxidol is related not only to a decrease in the intensity of lipid peroxidation (LPO), but also to the A2-phospholipasae activity of this drug.
Subject(s)
Cardiotonic Agents/pharmacology , Endotoxemia/drug therapy , Lipid Peroxidation/drug effects , Myocardium/metabolism , Phospholipases A2/metabolism , Pyridines/pharmacology , Animals , Disease Models, Animal , Dogs , Endotoxemia/etiology , Endotoxemia/metabolism , Female , Male , Peritonitis/drug therapy , Peritonitis/etiology , Peritonitis/metabolismABSTRACT
The chronic experiments on dogs with a pancreatitis model showed that reamberin involved in a complex therapy is conductive to timely positive clinical and laboratory dynamics of disease, particularly to the correction of lipid-induced distress syndrome, and leads to a significant decreasing in the incidence of pancreonecrosis. The positive effect of vitamin E is manifested to a lower degree. The lipid-controlling effect of antioxidants is realized due to a decrease not only in lipid peroxidation rate, but in the phospholipase A2 activity as well.
