ABSTRACT
Asthma is a chronic airway inflammatory disease listed as one of the top global health problems. Phaeanthus vietnamensis BÂN is a well-known medicinal plant in Vietnam with its anti-oxidant, anti-microbial, anti-inflammatory potential, and gastro-protective properties. However, there is no study about P. vietnamensis extract (PVE) on asthma disease. Here, an OVA-induced asthma mouse model was established to evaluate the anti-inflammatory and anti-asthmatic effects and possible mechanisms of PVE. BALB/c mice were sensitized by injecting 50 µg OVA into the peritoneal and challenged by nebulization with 5% OVA. Mice were orally administered various doses of PVE once daily (50, 100, 200 mg/kg) or dexamethasone (Dex; 2.5 mg/kg) or Saline 1 h before the OVA challenge. The cell infiltrated in the bronchoalveolar lavage fluid (BALF) was analyzed; levels of OVA-specific immunoglobulins in serum, cytokines, and transcription factors in the BALF were measured, and lung histopathology was evaluated. PVE, especially PVE 200mg/kg dose, could improve asthma exacerbation by balancing the Th1/Th2 ratio, reducing inflammatory cells in BALF, depressing serum anti-specific OVA IgE, anti-specific OVA IgG1, histamine levels, and retrieving lung histology. Moreover, the PVE treatment group significantly increased the expressions of antioxidant enzymes Nrf2 and HO-1 in the lung tissue and the level of those antioxidant enzymes in the BALF, decreasing the oxidative stress marker MDA level in the BALF, leading to the relieving the activation of MAPK signaling in asthmatic condition. The present study demonstrated that Phaeanthus vietnamensis BÂN, traditionally used in Vietnam as a medicinal plant, may be used as an efficacious agent for treating asthmatic disease.
ABSTRACT
This study provides information on the current situation of microplastics contamination in inland freshwater bodies in Vietnam. An urban drainage channel in Da Nang City was selected as a case study. Receiving mainly domestic wastewater and landfill leachate, the channel itself is becoming a microplastic pollution hotspot with a microplastic concentration of 1482.0 ± 1060.4 items m-3 in waters and 6120.0 ± 2145.7 items kg-1 in sediments. The dominant shapes of microplastics were fibers and fragments, in which the polymer types were mainly polyethylene, polypropylene, and polyethylene terephthalate. Microplastics with sizes ranging from 1000 to 5000 µm tended to be distributed primarily in surface waters, whereas particles from 300 to 1000 µm accumulated in sediments. The channel places Da Nang Bay at a high risk for microplastic pollution, with an estimated pollution load of approximately 623 × 106 items d-1 in dry weather.
Subject(s)
Microplastics , Water Pollutants, Chemical , Environmental Monitoring , Plastics , Vietnam , Wastewater , Water Pollutants, Chemical/analysisABSTRACT
Microplastics in shoreline sediments were investigated from Da Nang beach for the first time. Sediment samples at the two depth strata (0-5 cm and 5-10 cm) at eight sites along the entire coast were collected for identifying the characteristics of microplastics, including their concentration, size, shape, color, and nature. The synthetic fiber was the predominant type of microplastics, accounting for 99.2% of the total items. Blue (59.9%) and white (22.9%) were the most common colors of the fibers. Synthetic fibers showed a homogenous distribution at all sampling sites with a mean concentration of 9238 ± 2097 items kg-1 d.w. Meanwhile, the fibers tended to concentrate much more at the surface stratum than the deeper stratum. A large number of synthetic fibers (81.9%) were in the size range of 300-2600 µm, which might pose a threat to marine biota and human health.
Subject(s)
Plastics , Water Pollutants, Chemical , Environmental Monitoring , Geologic Sediments , Microplastics , Vietnam , Water Pollutants, Chemical/analysisABSTRACT
Lecane langsenensis n. sp. is described from two locations in Vietnam: Lang Sen Reserve, Long An Province, and the Huong River, Thua Thien Hue Province. It is distinguished from L. arcula, L. aculeata and L. superaculeata by its longer lorica, antero-lateral spine, and claws. Moreover, the size and shape of L. langsenensis, L. arcula, L. aculeata, and L. superaculeata were measured and compared. The results showed that these species are completely different.
