Association between muscle strength and depression in a cohort of young adults.

BACKGROUND: The study investigated the association between knee joint muscle strength and the prevalence of depression in a cohort of young adults. METHODS: The observational, population-based study was performed with 909 participants (29.02 ± 2.03 years; 48.73% male) from the Central European Longitudinal Studies of Parents and Children: Young Adults (CELSPAC: YA), who were retained to analysis. Quadriceps and hamstring knee muscle strength were assessed by isokinetic dynamometry, and depression by Beck's Depression Inventory (BDI-II). Statistical comparisons (Mann-Whitney and Chi-squared test) and effect size analyses (Eta-Squared, and Odds Ratio) were conducted. RESULTS: The main findings revealed an inverse association between knee joint muscle strength and depression, with individuals who had low muscle strength having 3.15 (95% CI = 2.74-3.62) times higher odds of experiencing depression. Specifically, participants with low extensor strength had 4.63 (95% CI = 2.20-9.74) times higher odds, and those with low flexor strength had 2.68 (95% CI = 1.47-4.89) times higher odds of experiencing depression compared to those individuals with high muscle strength. Furthermore, gender-specific analyses revealed that males with low muscle strength had 2.51 (95% CI = 1.53-4.14) times higher odds, while females had 3.46 (95% CI = 2.93-4.08) times higher odds of experiencing depression compared to individuals with high muscle strength. CONCLUSIONS: Strong knee muscles seems to be a key factor in preventing depression, specially in female young adults. The results support the importance of promoting an increase in muscle strength through physical activity as a preventive strategy against depression in this population.

How barefoot and conventional shoes affect the foot and gait characteristics in toddlers.

OBJECTIVES: Barefoot shoes have recently become a popular alternative to conventional shoes among the parents of pre-school children. As the long-term effect of habitual shoe-wearing on the foot is still unclear, the aim of this study was to compare the arch index, dynamic foot anthropometry and gait parameters in toddlers who had been habitually wearing barefoot shoes or conventional shoes since their first steps. METHODS: 30 toddlers- 15 habitually wearing barefoot shoes (BF group) and 15 habitually wearing conventional shoes (N-BF group)-participated in this study. Each child was measured twice during the study. The first data collection session occurred within one month after the first five consecutive unsupported steps were performed by the toddler. The second data collection session occurred seven months after this event. At each data collection session, the toddler was instructed to walk barefooted at its natural speed over an Emed® platform (Novel GmbH, Germany). The Emed ® software generated data regarding the arch index, dynamic foot anthropometry, foot progression angle, contact area, contact time, peak pressure and maximum force. The Wilcoxon signed-rank test was used to compare the differences between the 1st and 2nd data collections. The Mann-Whitney U test was used to compare the differences between the BF and N-BF groups. RESULTS: The results of this study show a higher plantar arch and a smaller foot progression angle in the BF group. The forefoot width in both the BF and N-BF groups remained proportional to the foot length after seven months of independent walking. CONCLUSIONS: These findings may encourage parents and caregivers to introduce barefoot shoes or create a habitual barefoot time for their child.

Changes in plantar pressure, contact area and contact time symmetry during the gait 4 weeks before and 12 and 24 weeks after unilateral total hip arthroplasty.

BACKGROUND: Foot to ground pressure changes in total hip arthroplasty patients' gait are not widely described, although they are sensitive to gait abnormalities and the distribution of plantar pressures may differ before and after the surgery. This study aimed to analyse longitudinally differences in plantar pressure during gait in total hip arthroplasty patients compared to healthy controls. METHODS: Eighteen males participated in this study. Eight males, who underwent unilateral total hip arthroplasty, participated at the data collection three times: 4 weeks before the surgery, 12 and 24 weeks after, and ten healthy controls. All participants were asked to walk over Emed platform. To compare differences between the affected and unaffected limbs, Kolmogorov-Smirnov test was used. Kruskal-Wallis test was used to compare the difference between total hip arthroplasty patients and healthy controls. FINDINGS: Statistically significant differences between the affected and unaffected limb were observed only during the preoperative measurement in peak pressure at MH4 area and in the contact area at MH4 and big toe. When comparing total hip arthroplasty patients and controls, a difference in the contact time at MH2, MH3 and MH4 areas 12 weeks after surgery and at MH2 and MH4 24 weeks after the surgery were observed. INTERPRETATION: The shorter contact time at forefoot areas may indicate an alteration in the propulsive phase of the gait of both the affected limb and unaffected limb in total hip arthroplasty patients as a result of decreased terminal hip extension during the stance phase described in previous studies.

Could the Evaluation of Muscle Strength Imbalances Be Used as a Predictor of Total Hip Arthroplasty?

Loss of muscle strength characterizes the period before total hip arthroplasty (THA). Little is known about whether muscle strength imbalances caused by muscle strength decline could be considered another clinical predictor for THA. This study aimed to determine whether muscle imbalances may be used as a clinical predictor for THA surgery. Thirty-six participants were enrolled in the study. Eighteen patients had THA (THA group), while 18 were healthy elders (CON group). Ipsilateral (H/Q) and bilateral (% Def) muscle imbalances of the knee were assessed. THA patients showed impairment of the extensors on the affected extremity compared to those unaffected. A comparison between the groups proved there were weakened flexors in the THA group on both extremities. A comparison of the imbalances revealed a significant bilateral imbalance of the extensors and ipsilateral imbalance of both extremities in the THA group. We computed two logistic regressions using bilateral and ipsilateral imbalance as the predictors of THA surgery. We found that bilateral extensor imbalance may be used as a predictor for THA (Nagelkerke R2 = 0.22). A decrease of the bilateral extensors imbalance by 8% decreases the probability of THA by 8%. The most interesting finding is that the evaluation of the bilateral extensor imbalance may be used as another clinical predictor for THA.

The Impact of Different Periods of Walking Experience on Kinematic Gait Parameters in Toddlers.

This study aimed to analyse the kinematic differences in gait between three groups of toddlers who differed in their weeks of independent walking (IW) experience, but not in anthropometrical characteristics, to determine the relationship between walking experience without the side effect of morphological differences on gait parameters. Twenty-six toddlers participated in this study. Depending on the week of their IW, toddlers were divided into three groups: Group 1 (1-5 weeks of IW), Group 2 (6-10 weeks of IW), and Group 3 (11-15 weeks of IW). Each toddler walked barefooted over a 2-m long pathway, and 3D kinematic data were obtained. A decrease in the upper limb position, hip flexion, and step width, i.e., changes towards the adult gait pattern, were observed in Group 3. Less experienced walkers exhibited a wider step width despite no statistically significant difference in body mass and height between groups. Results of this study show no statistically significant difference in step length between groups, suggesting that step length is more related to height than to the walking experience. The increased step length in more experienced walkers reported in previous studies may therefore be a result of different heights and not walking experience.

3D kinematic analysis of patients' gait before and after unilateral total hip replacement.

PURPOSE: The purpose of the study was to describe changes in the kinematic parameters in the patients' gait after total hip replacement. METHODS: Research group of men in the end stage of osteoarthritis indicated to the THR (n = 10; age 54.1 ± 7.5 years; weight 92.2 ± 9.6 kg; height 179.7 ± 5.9 cm). All participants underwent a total of three measurements: before surgery, 3 and 6 months after the surgery. Using the 3D kinematic analysis system, the patients' gait was recorded during each measurement session and kinematic analysis was carried out. The parameters that were monitored included the sagittal range of motion while walking in the ankle, the knee and the hip joints of the operated and the unoperated limb, and the range in the hip joint's frontal plane, the rotation of pelvis in the frontal and transverse planes, as well as the speed of walking and the walking step length. RESULTS: Significant increases were found in sagittal range of motion in the operated hip joint, sagittal range of motion in the ankle joint on the unoperated side and in the walking step length of the unoperated limb. CONCLUSIONS: During walking after a THR, the sagittal range of motion in the ankle of the unoperated limb increases. Also, the range of motion in the sagittal plane on the operated joint increases, which is related to the lengthening of the step of the unoperated lower limb.

The relationship between body composition and foot posture index in Special Olympics athletes.

PURPOSE: In Special Olympics, athletes' foot deformities, abnormal postural patterns and overweight and obesity were observed to be more common than in the general population. Therefore, the purpose of this study was to analyze the relationship between body composition and foot posture index. Additionally, the effect of gender and other factors on the body composition and foot posture index in athletes with intellectual disability (ID) were analyzed. METHODS: 131 athletes with ID participated in this study: 36 table tennis players, 66 cross country skiers and 29 downhill skiers. Their body composition was assessed using the bioimpedance analysis InBody 230 (Biospace, Korea). The foot screening included the assessment of foot posture index, which evaluates the degree of pronated, supinated and neutral position of the foot, gait speed and the last part of the procedure consisted of a short questionnaire, providing the information about the type of housing, age, and the usage of orthotics. RESULTS: A low correlation between body composition and some of the foot posture index criteria was observed. The mean foot posture index score in athletes with ID was observed to be slightly pronated, as also described in the general population, with no statistically significant difference between female and male athletes. The gender differences were observed only in body composition. CONCLUSIONS: The high body weight and body fat percentage observed in this study highlight the need for healthy lifestyle education in athletes with ID.

Dependence of the immune response to coccidiosis on the age of rabbit suckling.

To study the immune response to coccidiosis, the suckling rabbits were inoculated with 2,000 oocysts of either Eimeria intestinalis or Eimeria flavescens at 19, 22, 25, 29, and 33 days of age (DA) and in the case of E. intestinalis at 14 and 16 DA as well and sacrificed 14 days later. Another group served as an uninfected control and the rabbits were killed at the same age as their infected counterparts. Unlike the antibody response, the parameters reflecting cellular immunity (total number of leukocytes in mesenteric lymph nodes, lymphocyte proliferation upon stimulation with specific antigen and the dynamics of CD4+ and CD8+ cell proportions in the intestinal epithelium at the specific site of parasite development) were significantly changed from about 25 DA onwards. In contrast to the rabbits infected with weakly immunogenic coccidium E. flavescens, the proportions of CD4+ and CD8+ lymphocytes in intraepithelial lymphocytes from the specific site of parasite development were considerably changed after infection with highly immunogenic species E. intestinalis. As the immune system of sucklings from about 25 DA reacts to the infection, this age may be considered in terms of vaccination against coccidiosis.

Immune response to rabbit coccidiosis: a comparison between infections with Eimeria flavescens and E. intestinalis.

Seven- to eight-week-old rabbits were infected with Eimeria intestinalis Cheissin, 1948, a highly immunogenic coccidium, or Eimeria flavescens Marotel et Guilhon, 1941, which is weakly immunogenic. Immune response was investigated at 7, 14 and 21 days post inoculation (DPI). The level of serum immunoglobulins, lymphocyte proliferation stimulated by parasite antigens and weight of mesenteric lymph nodes (MLN) showed similar dynamics in rabbits inoculated with both coccidia species. The amount of serum IgG and IgM, but not IgA, was increased from 14 DPI. The lymphocytes from MLN of infected animals significantly reacted to stimulation with parasite antigen 14 and 21 DPI and MLN were enlarged at 14 DPI. Thus, both parasite species elicited immune response characterized by these parameters in a similar manner despite of their different immunogenicity. The only apparent difference in the responses was in the percentage of CD8+ lymphocytes in the specific site of parasite development (the last third of the small intestine in E. intestinalis, caecum in E. flavescens), which increased in rabbits infected with E. intestinalis but not with E. flavescens. This parameter reflects the status of local immunity and hence the results suggest that the local reaction plays an important role in induction of protective immunity to coccidia in rabbits.