ABSTRACT
The authors assess a possibility of the use of the BT 795/P outfit for aortocoronary shunting in 120 patients with coronary heart disease. Emphasize a considerable decrease in the requirement for donor's blood transfusion to patients undergoing intraoperative blood reinfusion by means of the BT 795/P outfit.
Subject(s)
Blood Transfusion, Autologous/instrumentation , Extracorporeal Circulation , Myocardial Revascularization , Humans , Intraoperative Period , MaleABSTRACT
Cardiosurgery with artificial circulation (AC) is attended with activation of plasma cascade proteolytic systems, which leads to homeostatic disturbances and postoperative complications. AC with the use of specific proteinase plasma sorption in a column with sepharose-immobilized acid-base proteinase inhibitor from human urine prevents activation of proteinase in the plasma. Application of specific plasma sorption facilitates rapid restoration of the plasma protein concentration lowered during AC, improves the course of the postoperative period, and reduces the risk of pulmonary, cardiovascular, and nervous complications.
Subject(s)
Coronary Artery Bypass , Endopeptidases/blood , Extracorporeal Circulation , Adult , Female , Homeostasis , Humans , Male , Middle Aged , Postoperative Complications , Protease Inhibitors/pharmacologyABSTRACT
The use of a "Cell-Saver" technique prevented hyperproteolysis and deletion of proteinase inhibitors in the blood plasma of patients during cardiopulmonary bypass. The technique also improved the course of the postoperative period, decreased the incidence of lung complications and prevented effectively postoperative bleedings. A prognostic value of alpha 1-proteinase inhibitor to trypsin activity ratio in the blood plasma of patients subject of cardiopulmonary bypass surgery has been demonstrated.
Subject(s)
Endopeptidases/blood , Extracorporeal Circulation/methods , Blood Transfusion, Autologous , Cell Separation , Female , Humans , Male , Middle AgedABSTRACT
Results of 69 aortocoronary bypass operations with the use of microsurgery equipment were analysed. Perfusion was performed under conditions of constant flow, which made it possible to avoid transmissive pulsation, making difficulties for creating microanastomoses. One venous double opening canule was used with no drainage of the left ventricule, which made cannulation easier and created optimal technical conditions for the surgeon. Duration of extracorporeal blood circulation and frequency of intraoperational complications (cardiac failure, myocardial infarction) depended on the operational methods: initial creation of proximal anastomoses resulted in decreased duration of the perfusion, improved protection of myocardium and lower number of complications.
