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Effect of glycodelin on the production of vascular endothelial growth factor in cumulus cells.

Hayes, Ellen C; Dominguez, Celia E; Voelkel, Steven; Song, Mingqing; Shanti, Aida S; Murphy, Ana A.

Fertil Steril ; 85(5): 1553-6, 2006 May.

Article in English | MEDLINE | ID: mdl-16647384

ABSTRACT

Glycodelin modulates vascular endothelial growth factor (VEGF) production in cumulus cells in vitro. Patients with normal gonadotropin responses who were undergoing IVF demonstrated increased VEGF production to glycodelin, whereas poor responders had a decreased response to glycodelin.

Subject(s)

Glycoproteins/administration & dosage , Oocytes/drug effects , Oocytes/metabolism , Pregnancy Proteins/administration & dosage , Vascular Endothelial Growth Factor A/metabolism , Adult , Case-Control Studies , Cells, Cultured , Dose-Response Relationship, Drug , Female , Glycodelin , Humans

ABSTRACT

Subject(s)

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