Anti-GQ1b antibody syndrome presenting as acute isolated bilateral ophthalmoplegia: Report on two patients and review of the literature.

BACKGROUND: Miller Fisher syndrome (MFS) is an acute polyradiculoneuritis regarded as an uncommon clinical variant of Guillain-Barré syndrome (GBS). MFS is characterized by the acute onset of the clinical triad of ophthalmoplegia, cereballar ataxia and areflexia. Atypical forms of MFS presenting as isolated ophthalmoplegia without ataxia have been rarely described, mostly in adults. PATIENTS: We present two cases of acute isolated bilateral ophthalmoplegia in childhood, both occurring shortly after Campylobacter jejuni enteritis. Serum analysis of anti-ganglioside antibodies revealed elevated levels of anti-GQ1b IgG and IgM. We observed in both children complete spontaneous resolution several weeks after onset. CONCLUSION: The cases of the two patients confirm the rare but possible occurrence of atypical MFS in young children a few weeks after gastrointestinal infection. Identification of high levels of anti-GQ1b antibodies in the serum may help confirm the diagnosis of MFS even when its clinical presentation is incomplete.

Clinical predictors of the severity of bronchiolitis.

INTRODUCTION: Bronchiolitis is the most common serious, acute viral infection in infants. Besides the diagnostic and treatment challenges, the appropriate time and the need of hospitalization remain unanswered. We wonder whether clinical predictors such as age less than 6 months, respiratory frequency more than 45 breaths per minute and oxygen saturation less than 95% could be of any help in assessing the severity of the disease and the need for admission. MATERIALS AND METHODS: A prospective study was held in the emergency department from November 2000 to January 2002, in which each patient with positive nasopharyngeal respiratory syncytial virus was included. Other inclusion criteria were full-term birth, clinical signs of respiratory diseases, age between 2 weeks up to 24 months and no underlying illnesses such as bronchopulmonary dysplasia and chronic heart or lung diseases. The sensitivity, specificity and relative risk (RR) were calculated by statistical analyses. RESULTS: During the study period, 378 patients were included, 117 of whom were hospitalized (31%). Age less than 6 months (sensitivity 62%, specificity 72% and RR 2.68 ), respiratory frequency more than 45 breaths per minute (sensitivity 68%, specificity 82% and RR 4.57) and oxygen saturation less than 95% (sensitivity 68%, specificity 87% and RR 4.67) predicted the severity of the pulmonary disease and the need for admission. The cumulative analysis of the three parameters showed a specificity of 91% and a sensitivity of 86%, with a relative risk of 4.54 among those admitted into the hospital. Respiratory frequency more than 45 breaths per minute (sensitivity 76%, specificity 82% and RR 2.85) and oxygen saturation less than 95% (sensitivity 84%, specificity 86% and RR 2.65) were more significant than age less than 6 months (sensitivity 60%, specificity 70% and RR 3.70) in predicting the admission into the paediatric intensive care unit. CONCLUSION: Oxygen saturation less than 95%, respiratory frequency more than 45 breaths per minute and age less than 6 months in respiratory-distressed infants are important parameters to predict the need for admission and emphasize the severity of bronchiolitis.