[Treatment of trigeminal neuralgia with vincristine iontophoresis. A clinical pilot study.]. / Die Behandlung von Trigeminusneuralgien mittels Vincristin-Iontophorese : Eine klinische Pilotstudie.

Treatment of chronic pain disease is a scientific and clinical challenge encountered in all branches of medicine. Essential trigeminal neuralgia and chronic pain situations are noted for their exceptionally marked severity and also for their psychic and social consequences. It is not rare for a primarily somatic pain syndrome to develop into a painful disease in its own right, which is highly refractory to treatment. In transcutaneous iontophoresis of vincristine the neurotoxic effect of the alkaloid is employed locally and in a controlled manner. Iontophoresis of a microtubule inhibitor (vincristine, vinblastin) to the skin induces transganglionic degenerative atrophy of the central terminals of primary sensory neurons. Vincristine iontophoresis was applied in 33 patients hitherto unsuccessfully treated with various other methods. In 78% of the cases, attenuation of the pain was achieved. This noninvasive therapy proved to be free of side effects.

[Hemihypertrophia mandibulae--CT scans and histochemical findings]. / Hemihypertrophia mandibulae--Computertomografie und histochemische Befundung.

In a clinical statistical evaluation of patients seen in our hospital between 1967 and 1987 a total of 25 cases of facial asymmetry are assessed. The importance of CT scans for diagnosis and treatment planning is emphasized. The histochemical analysis of native cryostat hard bone tissue sections proves the existence of atypical bone remodelling processes in the inner bone surface late in the 3rd decade of life.

[Stimulated osteogenesis in bone cysts]. / Stimulierte Osteogenese bei Knochenzysten.

This method deduces from classical therapeuticál principle of bone jaw cysts from Partsch (1892, 1910) and Schulte (1959, 1960, 1964) and has regard the modern results of biomaterial research. It is used mixing of anorganic and organic materials, which proportion is in accordance to normal bone tissue. In 39 till now operated cases of different bone defects we attained good clinical events. The first cases are controlled since two years.