ABSTRACT
This study investigates the dosimetric feasibility of Boron Neutron Capture Therapy (BNCT) of explanted livers in the thermal column of the research reactor in Mainz. The Monte Carlo code MCNP5 is used to calculate the biologically weighted dose for different ratios of the (10)B-concentration in tumour to normal liver tissue. The simulation results show that dosimetric goals are only partially met. To guarantee effective BNCT treatment the organ has to be better shielded from all gamma radiation.
Subject(s)
Boron Neutron Capture Therapy/methods , Liver Neoplasms/radiotherapy , Liver Neoplasms/secondary , Models, Biological , Radiometry/methods , Computer Simulation , Humans , Liver Neoplasms/physiopathology , Radiotherapy DosageABSTRACT
For the application of the BNCT for the excorporal treatment of organs at the TRIGA Mainz, the basic characteristics of the radiation field in the thermal column as beam geometry, neutron and gamma ray energies, angular distributions, neutron flux, as well as absorbed gamma and neutron doses must be determined in a reproducible way. To determine the mixed irradiation field thermoluminescence detectors (TLD) made of CaF(2):Tm with a newly developed energy-compensation filter system and LiF:Mg,Ti materials with different (6)Li concentrations and different thicknesses as well as thin gold foils were used.
Subject(s)
Boron Neutron Capture Therapy/instrumentation , Nuclear Reactors , Boron/therapeutic use , Boron Neutron Capture Therapy/statistics & numerical data , Energy Transfer , Fast Neutrons/therapeutic use , Fluorides , Gamma Rays/therapeutic use , Germany , Humans , In Vitro Techniques , Isotopes/therapeutic use , Lithium Compounds , Liver Neoplasms/radiotherapy , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Liver Transplantation , Nuclear Reactors/statistics & numerical data , Phantoms, Imaging , Radiation-Sensitizing Agents/therapeutic use , Radiotherapy Planning, Computer-Assisted/statistics & numerical data , Thermoluminescent Dosimetry , Transplantation, AutologousABSTRACT
The TRIGA Mark II reactor at the University of Mainz provides ideal conditions for duplicating BNCT treatment as performed in Pavia, Italy, in 2001 and 2003 [Pinelli, T., Zonta, A., Altieri, S., Barni, S., Braghieri, A., Pedroni, P., Bruschi, P., Chiari, P., Ferrari, C., Fossati, F., Nano, R., Ngnitejeu Tata, S., Prati, U., Ricevuti, G., Roveda, L., Zonta, C., 2002. TAOrMINA: from the first idea to the application to the human liver. In: Sauerwein et al. (Eds.), Research and Development in Neutron Capture Therapy. Proceedings of the 10th International Congress on Neutron Capture Therapy, Monduzzi editore, Bologna, pp. 1065-1072]. In order to determine the optimal parameters for the planned therapy and therefore for the design of the thermal column, calculations were conducted using the MCNP-code and the transport code ATTILA. The results of the parameter study as well as a possible configuration for the irradiation of the liver are presented.
Subject(s)
Boron Neutron Capture Therapy/instrumentation , Liver Neoplasms/radiotherapy , Liver Neoplasms/secondary , Nuclear Reactors , Boron Neutron Capture Therapy/statistics & numerical data , Fast Neutrons/therapeutic use , Germany , Humans , In Vitro Techniques , Models, Statistical , Monte Carlo Method , Nuclear Reactors/statistics & numerical data , Radiotherapy Planning, Computer-Assisted/statistics & numerical dataABSTRACT
A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.
