1.
Ned Tijdschr Geneeskd
; 138(7): 363-5, 1994 Feb 12.
Article
in Dutch
| MEDLINE
| ID: mdl-8121527
ABSTRACT
A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.