ABSTRACT
The structure of leukocyte infiltrates in gingiva of 80 patients of various ages and gender with chronic apical periodontitis was studied using light microscopy with the application of monoclonal antibodies detecting CD38 antigen. Gingival tissues of practically of all the patients with periodontitis contained 2 types of leukocyte infiltrates: infiltrates with the low plasma cell content and high numbers of neutrophils and structures with high number of plasmocytes and low concentration of neutrophilic granulocytes. Within the gingival epithelium in patients with chronic apical periodontitis CD38 + cells were absent. The histogenesis of gingival leukocyte infiltrates in chronic apical periodontitis is discussed with the special emphasis on the role of plasma cells in the development of the pathological process.
Subject(s)
Chronic Periodontitis/pathology , Gingiva/pathology , Periapical Tissue/pathology , Plasma Cells/pathology , ADP-ribosyl Cyclase 1/immunology , Adolescent , Adult , Chronic Periodontitis/immunology , Female , Gingiva/immunology , Humans , Immunohistochemistry , Lymphocyte Count , Male , Middle Aged , Neutrophil Infiltration/immunology , Periapical Tissue/immunology , Plasma Cells/cytology , Plasma Cells/immunology , Young AdultABSTRACT
The structure of gingival mucous membrane leukocytal infiltration of 80 patients with chronic apical periodontitis of different age groups was studied by the light microscopy with the use of monoclonal antibodies to CD38. It was disclosed that in gingival tissues of practically all patients 2 types of leukocytal infiltration were present with low number of plasmatic cells and high number of neutrophils (true leukocytal infiltration) and structures with high number of plasmatic cells and low number of neutrophils - most likely lymphoid follicle resultant in mucous membranes of different organs in cases of chronic inflammation. In epithelial gingival paving in cases of chronic apical periodontitis CD38(+)-cells were absent.
