[An analysis of the antibodies to the outer cell membrane proteins in Yersinia in the varying course of human pseudotuberculosis]. / Analiz antitel k belkam naruzhnoi kletochnoi membrany iersinii pri razlichnom techenii psevdotuberkuleza u liudei.

Time course changes in the formation and spectrum of the antibodies to the proteins of Yersinia pseudotuberculosis external cellular membrane were studied by immunoblotting. A total of 154 samples of blood serum from 46 pseudotuberculosis (PT) patients were tested. 53 samples were obtained from PT patients with acute disease, 50 from PT patients with recurrences and 51 samples cam from PT subjects with protracted disease. Electrophoresis in polyacrylamide gel with sodium dodecyl sulfate disclosed a number of basic protein components with molecular characteristics: 22-26-33-37-45-59-67 kD. Irrespective of the disease clinical presentation, the antibodies were directed primarily to the protein component of 26 kD molecular mass this evidencing its immunodominant role. There appeared some specific features in formation rate and circulation time of the above antibodies. This finding may be utilized for diagnostic and prognostic purpose.