ABSTRACT
The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Biological Factors/administration & dosage , Cancer Vaccines/administration & dosage , Cisplatin/administration & dosage , DNA Adducts/administration & dosage , Neoplasms, Experimental/drug therapy , Animals , Dose-Response Relationship, Drug , Drug Screening Assays, Antitumor , Female , Male , Mice , Mice, Inbred BALB C , Mice, Inbred C57BL , Neoplasm Transplantation , Time Factors , Yersinia enterocoliticaABSTRACT
Results of the action of a preparation consisting of cis-dichlorodiammineplatinum and deoxyribonucleic acid combined in the saline balanced solution by means of the original technique on cytomegalovirus infection of patients with cancer of the liver are presented. Clearly pronounced antivirus activity of the preparation developed is noted.
Subject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Hepatocellular/drug therapy , Cytomegalovirus Infections/drug therapy , Liver Neoplasms/drug therapy , Organoplatinum Compounds/therapeutic use , Adult , Carcinoma, Hepatocellular/virology , Cytomegalovirus Infections/virology , DNA, Neoplasm/biosynthesis , Humans , Liver Neoplasms/virology , Macromolecular Substances , Male , Treatment OutcomeABSTRACT
The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.
Subject(s)
Antineoplastic Agents/therapeutic use , Cisplatin/therapeutic use , DNA Adducts , DNA/therapeutic use , Leukemia P388/drug therapy , Animals , Dose-Response Relationship, Drug , Drug Screening Assays, Antitumor , Humans , Mice , Mice, Inbred DBA , Neoplasm Transplantation , Time Factors , Tumor Cells, Cultured/drug effectsABSTRACT
Results of the use of polyplatillen--a preparation consisting of sodium nucleinate (deoxyribonucleic acid) and cisplatin combined in the saline balanced solution by means of the original technique--in cancer of the ovaries (198 patients), liver (62), pancreas (35), lungs (12), stomach (5) are presented. Clearly pronounced specific activity of the preparation developed is noted.
Subject(s)
Antineoplastic Agents/therapeutic use , Cisplatin/administration & dosage , Cisplatin/therapeutic use , Digestive System Neoplasms/drug therapy , Lung Neoplasms/drug therapy , Nucleic Acids/administration & dosage , Ovarian Neoplasms/drug therapy , Digestive System Neoplasms/mortality , Digestive System Neoplasms/pathology , Drug Combinations , Female , Humans , Lung Neoplasms/mortality , Lung Neoplasms/pathology , Neoplasm Staging , Ovarian Neoplasms/mortality , Ovarian Neoplasms/pathology , Remission Induction , Time FactorsABSTRACT
Toxic action of polyplatillen, a principally new platinum compound, was studied on laboratory animals and cell culture. When compared with cis-dichlorodiamminplatinum, the preparation is 10-fold less toxic in animals and 100-fold--in the cellular systems. Reversibility of damaging action of polyplatillen at "non-toxic" dosages conditions the perspectiveness of its further clinical trials.