ABSTRACT
The results of kidney transplantation from very young paediatric cadaveric donors up to five years, which were transplanted to adult recipients, are evaluated in the first retrospective study of all Czech transplantcentres. In general, 42 of these transplantations were carried out during 1994-2001. In 28 cases single kidney was transplanted, in 14 cases en bloc graft of both children kidneys was transplanted. The reasons of kidney failure by recipients are usual (in 42.9% glomerulonephritis). An average age of the donors was 34.7 months (median 39 months). An average age of the recipients during transplantation was 42.6 years (median 43.5 years). All the kidneys were placed into retroperitoneum. As long as only single kidney was transplanted, the rules, already propagated by Salvatiera in 1970, were respected. At the transplantation of en bloc graft, Kinne's method with possible vessels elongation of the graft and with uretero-uretero anastomoses (in so called Ostrava modification) was used. The higher occurrence of the primary graft non-function (as 50% losses of all grafts) was confirmed in the study. Its reason was an acute thrombosis of vessels or rotation of graft stem. One-, three- and five-years patients and grafts survival were 97.6-90.5-90.5% and 76.2-73.8-73.8% actually. Patients survival are very good while grafts survival are average, momentarily a bit worse than national data published by the Czech Transplant Society, which determines one-, three- and five-years grafts survival with 90.3-82.9-75.5% and 79.1-71.1-65% actually. The kidney transplantation from paediatric cadaveric donors to adult recipients is acceptable under present allocated criteria, in case that some principles are kept. The study confirms the international experiences about rather higher incidence of surgical complications and primary graft non-function. In conclusion, some general references for reduction of complications, as well as for improvement of these transplantation results are introduced.
Subject(s)
Kidney Transplantation , Tissue Donors , Adult , Age Factors , Cadaver , Child, Preschool , Czech Republic , Humans , Kidney Transplantation/mortality , Kidney Transplantation/statistics & numerical dataSubject(s)
Anesthesia, General , Kidney Transplantation , Adult , Anesthetics, Inhalation , Anesthetics, Intravenous , Female , Humans , Kidney Failure, Chronic/surgery , Male , Methyl Ethers , Middle Aged , Piperidines , Remifentanil , SevofluraneABSTRACT
The present paper investigates the antibiotic properties of the novel antifungal antibiotic agent cortalceron and its semisynthetic derivative cortalceron 7-diphenylhydrazone. The MIC values were assayed by the agar diffusion method. Cortalceron was found to weakly inhibit the growth of E. coli and B. subtilis. The growth of yeast was not influenced. On i.v. administration to mice [correction of rats], the agent produced breathing disorders and convulsions which later disappeared. The diphenylhydrazine derivative of cortalceron inhibited the growth of most yeasts tested as well.
Subject(s)
Anti-Bacterial Agents/pharmacology , Animals , Anti-Bacterial Agents/toxicity , Antifungal Agents/pharmacology , Bacteria/drug effects , Fungi/drug effects , Hydrazones/pharmacology , Hydrazones/toxicity , Mice , Mice, Inbred C57BL , Microbial Sensitivity Tests , Pyrones/pharmacology , Pyrones/toxicityABSTRACT
No changes in immunoglobulin (IgG, IgM and IgA) and complement components C3 and C4 levels could be observed in patients suffering from both recurrent and acute nasal polyposis. However, in both groups of patients a significant decrease of the alternative pathway of complement activation (up to 80%) was found. In addition, patients suffering from the acute disease showed even decreased classical complement pathway (up to 20%). Examination of complement activation pathways was shown to be advantageous for the follow-up of the course of this disease.
Subject(s)
Complement C3/analysis , Complement C4/analysis , Complement Pathway, Alternative , Nasal Polyps/immunology , Acute Disease , Adult , Aged , Female , Follow-Up Studies , Humans , Immunoglobulins/biosynthesis , Male , Middle Aged , Nasal Polyps/blood , RecurrenceABSTRACT
The authors present the case-histories of two successfully treated patients following injury of the infrarenal part of the abdominal aorta. The injury occurred during extirpation of sequestra of discs of lumbar vertebrae. Some problems of the tactics of surgical treatment are discussed.
