ABSTRACT
An analysis of results of 498 patients with malignant pleural effusion was made. All patients were divided into three groups depending on methods of treatment: in the first group of patients the puncture of pleural cavity and the evacuation of liquid were made against the background of complex treatment; in the second group of patients the thoracocentesis and suspension induction were performed; in the third group the video thoracoscopy was carried out. In an assessment of each method of treatment, the researchers came to the conclusion that in case when the patient had the sufficient functional capabilities, the doctors should give preference to the thoracoscopy operations and in case of severe somatic status the doctors should give preference to the drainage of pleural cavity with release from exudates and with subsequent introduction of talc as the most effective sclerosing agent.
Subject(s)
Drainage/methods , Pleural Effusion, Malignant/therapy , Pleurodesis/methods , Thoracoscopy , Adult , Aged , Female , Follow-Up Studies , Humans , Male , Middle Aged , Pleural Cavity , Retrospective Studies , Sclerosing Solutions/administration & dosage , Talc/administration & dosage , Treatment OutcomeABSTRACT
The authors made an analysis of the results of treatment of 924 patients with non-small cell lung cancer, operated in the volume of pneumonectomy during 1990-2007 years and developed a method of complete suturing the mediastinum wound in order to isolate the bronchus stump from the free pleural cavity and prevention of the development of a bronchopleural fistula.
Subject(s)
Bronchial Fistula/etiology , Lung Neoplasms/surgery , Pneumonectomy/adverse effects , Pneumonectomy/methods , Small Cell Lung Carcinoma/surgery , Adult , Aged , Bronchial Fistula/surgery , Female , Humans , Male , Middle Aged , Retrospective StudiesABSTRACT
The authors investigated the dependence of increasing serum oncomarkers CEA, Cyfra-21, NSE, TU M2-PK on survival in 739 patients with nonsmall cell lung cancer. The tests for the determination of the content of CEA, Cyfra-21, NSE in blood serum have low sensitivity and are of little use for the diagnosis of lung cancer. The tests because of their simplicity and low cost can be used for the detection of groups of patients with preliminarily diagnosed nonsmall cell lung cancer needing additional methods of examination for more exact staging of the disease and exclusion of remote metastases and more active using adjuvant method of treatment. The use of tumor pyruvate kinase can be perspective for clinical oncopulmonology. However, due to its low specificity, further experiences are required for using this oncomarker in the group of patients with nonsmall cell lung cancer.
Subject(s)
Antigens, Neoplasm/blood , Biomarkers, Tumor/blood , Carcinoembryonic Antigen/blood , Carcinoma, Non-Small-Cell Lung/blood , Keratin-19/blood , Lung Neoplasms/blood , Phosphopyruvate Hydratase/blood , Pyruvate Kinase/blood , Adult , Aged , Aged, 80 and over , Carcinoma, Non-Small-Cell Lung/pathology , Carcinoma, Non-Small-Cell Lung/surgery , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Immunoenzyme Techniques , Immunoradiometric Assay , Luminescent Measurements , Lung Neoplasms/pathology , Lung Neoplasms/surgery , Male , Middle Aged , Neoplasm Staging , PrognosisABSTRACT
The test for the determination of the serum carcinoembryonic antigen was found to possess low specificity and to be of little use for the diagnosis of lung cancer. The test can be used for the detection of patients with diagnosed non-small-cell cancer of the lung for more exact staging of the disease and exclusion of distant metastases as well as for more active using adjuvant methods of treatment and for the dynamic observation of the course of the disease.
Subject(s)
Carcinoembryonic Antigen/blood , Carcinoma, Non-Small-Cell Lung/blood , Lung Neoplasms/blood , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/blood , Carcinoma, Non-Small-Cell Lung/pathology , Electrochemical Techniques , Female , Humans , Lung Neoplasms/pathology , Male , Middle Aged , Neoplasm Staging , Prospective Studies , Sensitivity and SpecificityABSTRACT
When lactoferrin (LF) and myeloperoxidase (MPO) are added to ceruloplasmin (CP), a CP-LF-MPO triple complex forms. The complex is formed under physiological conditions, but also in the course of SDS-free PAGE. Polyclonal antibodies to both LF and MPO displace the respective proteins from the CP-LF-MPO complex. Similar replacement is performed by a PACAP38 fragment (amino acids 29-38) and protamine that bind to CP. Interaction of LF and MPO with CP-Sepharose is blocked at ionic strength above 0.3 M NaCl and at pH below 4.1 (LF) and 3.9 (MPO). Two peptides (amino acids 50-109 and 929-1012) were isolated by affinity chromatography from a preparation of CP after its spontaneous proteolytic cleavage. These peptides are able to displace CP from its complexes with LF and MPO. Both human and canine MPO could form a complex when mixed with CP from seven mammalian species. Upon intravenous injection of human MPO into rats, the rat CP-human MPO complex could be detected in plasma. Patients with inflammation were examined and CP-LF, CP-MPO, and CP-LF-MPO complexes were revealed in 80 samples of blood serum and in nine exudates from purulent foci. These complexes were also found in 45 samples of serum and pleural fluid obtained from patients with pleurisies of various etiology.
