[Insulin and C-peptide secretion after physical exertion in men with newly manifested stenocardia and chronic ischemic heart disease]. / Sekretsiia insulina i C-peptida pri fizicheskoi nagruzke u muzhchin s vpervye voznikshei stenokardiei i khronicheskoi ishemicheskoi bolezn'iu serdtsa.

Variation in insulin and C peptide levels was examined in patients with angina of new onset and chronic coronary heart disease. Insulin secretion was increased in all coronary patients, as compared to the controls, and hormonal response to additional stress was abnormal in postmyocardial infarction patients. It is demonstrated that insulin secretion is already changed at early stages of coronary disease, and the pattern of change is presented.

[Relation of the levels of thyroid hormones and cortisol and the degree of systolic arterial pressure in 11- and 12-year-old boys]. / Sviaz' kontsentratsii tireoidnykh gormonov i kortizola s urovnem sistolicheskogo arterial'nogo davleniia u mal'chikov 11-12 let.

An epidemiologic evaluation of relationships between arterial BP changes, and thyroid and adrenocortical hormones was carried out in eleven- and twelve-year-old boys. Different patterns of correlation were demonstrated between plasma thyrotropic hormone, thyroid hormones and cortisol levels, on one hand, and systolic BP variation, on the other. There was a correlation between thyroid hormones and cortisol in these groups. The results suggest that even slight changes in thyroid and adrenal function may promote disorders of BP regulation.

[Activation of glucocorticoid cytoreceptors in rat heart]. / Aktivatsiia gliukokortikoidnogo tsitoretseptora serdtsa krysy.

Accumulation of 3H-dexamethasone by the nuclei in a cell-free system was studied. The increase in temperature from 0 degrees to 20 degrees C and treatment of cytosol by KCl (0.4 M) or theophylline (10mM) significantly increased the absorption the bound hormone by the nuclear fraction. Activation of the steroid-protein complex induced by temperature and addition of theophylline did not change its size. The increase in the ionic strength decreased the Stokes radius from 53 A down to 39.5 A and the sedimentation coefficient value from 7S down to 4S. It is concluded that the heart tissue cytoplasm contains a glucocorticoid receptor.

[Binding of glucocorticoids by a transcortin-like protein in the cytoplasmic fraction of rat myocardium]. / Sviazyvanie gliukokortikoidov transkortinopodobnym belkom tsitoplazmaticheskoi fraktsii miokarda krys.

Myocardial cytosol of adult adrenalectomized rats bound specifically 3H-corticosterone and 3H-hydrocortisone and did not bind the synthetic 9alpha-fluoroglucocorticoid (dexamethasone) in vitro at 0-4 degrees. The specific binding of dexamethasone was not also found in the cytosol of neonatal rats. Heating of myocardial cytosol of adrenalectomized rats within 10 min at 60 degrees led to the complete loss of the glucocorticoid-binding activity. Treatment of the cytosol within the same period but at the temperature lower than 55 degrees did not affect its binding capacity. 3H-corticosterone-cytoreceptor complex was precipitated by ammonium sulphate at 40-60% of saturation. The complex was eluted from a column of Sephadex G-150 by solutions with both low (0.015 M KCl) and high (0.4 M KCl) ionic strength as the alone peak. This fraction corresponded by molecular weight to the transcortin complex. The data obtained and the results of our previous investigations suggest that myocardial glucocorticoid-binding cytoplasmic protein is related to transcortin-like cytoreceptors.

[Effect of several surface-active substances on the biological and mechanical properties of a catalase monolayer]. / Vliianie nekotorykh poverkhnostno-aktivnykh veshchestv na biologicheskie i mekhanicheskie svoistva monosloia katalazy

It is found out that surface pressure of catalase monolayers increases when some medicinal surface-active agents are added to its substrate, while its enzymic activity decreases depending on the increase of surface activity of the medicinal substance. Catalase monolayer viscosity grows with a decrease in the area. The viscosity decreases with a rise in the dimedrol concentration in the substrate. The same is recorded for the shear module. As to the shear stress characterizing the strength of the monolayers it decreases with the addition of medicinal substances. This change in rheological properties of the catalase monolayer evidences for its structural destruction with an increase in the mixed monolayer pressure.