ABSTRACT
This study was designed to analyze results of daptomycin therapy in 7 patients with enterococcal infectious endocarditis caused by Enterococcus faecium in two of them. Mean duration of therapy was 36.7 days. 70% of the strains proved resistant to gentamycin, 40% showed resistance to penicillin antibiotics, and 14.3% to vancomycin. Three patients suffered prosthetic valve endocarditis, six had elevated presepsin level (up to 768.8 pg/ml). 28,6% of the patients underwent valve prosthetic surgery. Hospital lethality was 14,3%. The effectiveness of ampicillin plus ceftriaxone treatment of gentanycin-resistant enterococci is discussed. Recommendation for the antibacterial treatment of enterococcal infectious endocarditis (ESC 2015) are provided.
Subject(s)
Daptomycin/administration & dosage , Endocarditis, Bacterial , Enterococcus faecium , Gram-Positive Bacterial Infections , Anti-Bacterial Agents/administration & dosage , Echocardiography/methods , Endocarditis, Bacterial/diagnosis , Endocarditis, Bacterial/microbiology , Endocarditis, Bacterial/mortality , Endocarditis, Bacterial/therapy , Enterococcus faecium/drug effects , Enterococcus faecium/isolation & purification , Female , Gram-Positive Bacterial Infections/diagnosis , Gram-Positive Bacterial Infections/microbiology , Gram-Positive Bacterial Infections/mortality , Gram-Positive Bacterial Infections/therapy , Heart Valve Prosthesis/microbiology , Heart Valves/microbiology , Humans , Male , Middle Aged , Russia/epidemiology , Survival Analysis , Treatment OutcomeABSTRACT
The proposed reconstructive operation in patients with locally advanced laryngeal cancer. The operation implies removal of the tumor-affected half of the larynx with reconstruction of the lost structures. The resected upper corniculum of the thyroid cartilage is preserved and sutured to the stump of the cricoid cartilage seal. The lateral laryngeal wall is created from cervical skin. The proposed technique was used in surgery of 30 patients. They recovered swallowing, respiratory and speech functions.
