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[DEXMEDETOMIDINE--THEORY OR EXPERIENCE?].

Volkov, P A; Churadze, B T; Sevalkin, S A; Volkova, Yu N; Guryanov, V A.

Anesteziol Reanimatol ; 60(2): 68-71, 2015.

Article in Russian | MEDLINE | ID: mdl-26148368

ABSTRACT

So far, the ongoing debate about the appropriateness of combining drugs with different mechanisms of analgesic action for optimal antinociceptive protection. The review deals with the theoretical calculations arguing with the physiological rationality for the inclusion of central α2-agonists in the scheme of modern multimodal analgesia. We have presented data from recent reviews regarding the efficacy and safety of intraoperative application of dexmedetomidine as a one of the latest drugs in this class.

Subject(s)

Adrenergic alpha-2 Receptor Agonists/therapeutic use , Analgesics, Non-Narcotic/therapeutic use , Dexmedetomidine/therapeutic use , Pain/drug therapy , Adrenergic alpha-2 Receptor Agonists/administration & dosage , Adrenergic alpha-2 Receptor Agonists/adverse effects , Adrenergic alpha-2 Receptor Agonists/pharmacokinetics , Analgesics, Non-Narcotic/administration & dosage , Analgesics, Non-Narcotic/adverse effects , Analgesics, Non-Narcotic/pharmacokinetics , Dexmedetomidine/administration & dosage , Dexmedetomidine/adverse effects , Dexmedetomidine/pharmacokinetics , Drug Therapy, Combination , Humans , Pain/metabolism , Receptors, Adrenergic, alpha-2/metabolism , Signal Transduction , Synaptic Transmission/drug effects , Tissue Distribution

ABSTRACT

Subject(s)

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