[Several aspects of the pathogenesis of chronic circulatory failure in ischemic heart disease: role of atrial natriuretic peptide]. / Nekotorye aspekty patogeneza khronicheskoi nedostatochnosti krovoobrashcheniia pri ishemicheskoi bolezni serdtsa: rol' predserdnogo natriiureticheskogo peptida.

Alpha-atrial natriuretic peptide (ANP) levels, plasma renin activity, and plasma aldosterone levels were measured in 103 patients with coronary heart disease (CHD) having signs of various circulatory failures. The parameters were studied in relation to central hemodynamic values, and their dependence on the stage of chronic circulatory failure. Alpha-ANP was found to be one of the factors of the humoral systems implicated in the pathogenesis of chronic circulatory failure in CHD patients. The plasma level of alpha-ANP was found to be related to the state of the renin-angiotensin-aldosterone system both in healthy subjects and CHD patients.

[Atrial natriuretic peptide in chronic circulatory failure in patients with ischemic heart disease]. / Predserdnyi natriiureticheskii peptid pri khronicheskoi nedostatochnosti krovoobrashcheniia u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The content of human precordial natriuretic peptide (alpha-HPNP) was examined in 26 patients suffering of chronic ischemic heart disease with different stages of circulatory insufficiency. It is suggested that alpha-HPNP participates in the pathogenesis of circulatory insufficiency in patients with chronic ischemic heart disease and depended on the stage of circulatory insufficiency.

[Topical use of Rheumon-Gel in the combined treatment of patients with rheumatoid arthritis]. / Mestnoe primenenie preparata Rheumon-Gel v kompleksnom lechenii bol'nykh revmatoidnym artritom.

Rheumon-Gel was used for therapy of 51 patients with rheumatoid arthritis. It has been shown that the drug has a marked antiinflammatory and analgesic action, a positive effect on a number of subjective (pain in the joints and constrained movements in the morning), objective (body temperature, edema and joint function), and laboratory (leucocyte count, ESR, C-reactive protein, titer of antistreptolysin-O and antistreptohyaluronidase) indices and therefore it can be recommended for multimodality therapy of rheumatic patients, particularly of those with rheumatoid arthritis combined with G. I. tract diseases when the use of most of the antirheumatic drugs is counterindicated.