ABSTRACT
INTRODUCTION: Chronic rhinosinusitis (CRS) is the most common immunological ENT disease, which has several phenotypes. The heterogeneity of CRS is due to the peculiarities of their pathogenetic mechanisms - the system of cytokines plays the crucial significance. They are biologically active substances and present regulatory peptides that demonstrate an immunomodulatory and regulatory effects not only in the local level but the system level as well. OBJECTIVE: To determine specific features of the cytokine profile in blood serum among patients with CRS without polyps (CRSwP). MATERIAL AND METHODS: Serum cytokines (IL-1α, IL-1RA, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IL-17, IFN-α2, IFN-γ, GM-CSF) were defined in 75 patients: 32 patients with CRSwP were operated (main group) - 17 with cyst of maxillary sinus, 15 with edema of the maxillary sinuses. The control group - 43 patients were under surgery for a deviated nasal septum (septoplasty). The groups were comparable to gender and age. RESULTS: The cytokines detection rate was different in all groups. IL-4 (detection rate 93.3-95.3%) and IFN-γ (79.1-86.7%) were measured nearly the all groups. IL-8 (73.3-76.5%) and IL-17 (76.5-80.0%) were often measured in the group with CRSwP; in contrast to the control group - these indicators were lower: 60.5% and 65.5%, respectively. IL-1α (82.4%) and IFN-α2 (76.5%) were often detected in CRS with cystic formations. IL-1ß, IL-5, IL-7, IL-9, IL-15 were measured in all groups in less than 30% of patients; IL-2 and IL-6 - in the group of CRS with cystic formation; IL-10, IL-12p40, IL-13 in the group with edema of maxillary sinuses. In a quantitative comparison of the concentration of cytokines. Significant differences in concentration of cytokines between the groups were not obtained (p>0.05) in terms of quantity. CONCLUSION: CRSwP with cystic formation is characterized by the development of T2 type immune response and a higher inflammation-related tissue damage.
Subject(s)
Granulocyte-Macrophage Colony-Stimulating Factor , Nasal Polyps , Cytokines , Humans , Interleukin 1 Receptor Antagonist Protein , Interleukin-10 , Interleukin-12 Subunit p40 , Interleukin-13 , Interleukin-15 , Interleukin-17 , Interleukin-2 , Interleukin-3 , Interleukin-4 , Interleukin-5 , Interleukin-6 , Interleukin-7 , Interleukin-8 , Interleukin-9 , Nasal Polyps/complications , Nasal Polyps/diagnosis , Nasal Polyps/surgeryABSTRACT
Increasing number of patients with allergy observed in recent years is accompanied with increasing number of health encounters due to acute allergy. The sudden beginning and unpredictable course characterize acute allergy. These factors can be fatal for patient and must be treated immediately. Allergic rhinitis, allergic conjunctivitis, acute urticaria, angioedema and anaphylaxis refer to diseases based on acute allergy. The most dangerous diseases, characterized by fatal conditions, are generalised urticaria, angioedema and anaphylaxis. Knowledge of first aid principles is the most important factor of effective treatment because quickness of allergy progression requires prompt decisions. Use of the whole complex of modern therapeutic possibilities is the most important and durable. Modern methods of first aid for acute allergy, based on recommendations from foreign and domestic publications, are given in the article.
Subject(s)
Hypersensitivity , Military Medicine/methods , Acute Disease , Female , Humans , Hypersensitivity/diagnosis , Hypersensitivity/mortality , Hypersensitivity/therapy , Male , Military Medicine/standards , RussiaABSTRACT
The article deals with contact dermatitis issues, that are of interest not only for dermatologists and specialists in professional pathology, but as well as for general practitioners. Issues of contact dermatitis classification, pathogenic peculiarities of the disease main forms and their basic causes are discussed. Clinical manifestations of irritative and allergic contact dermatitis are described in detail, aspects of differential diagnostics analysed. A detailed consideration is given to allergic diagnostics of contact dermatitis using application test-systems with the most common contact allergens. Main principles of contact dermatitis treatment are outlined in the article. The necessity of a complex approach to this disease therapy that requires not only external therapy, but the compliance with an appropriate treatment regimen, diet as well as application of a particular system therapy is shown. Recommendations for contact dermatitis prophylaxis are given.
Subject(s)
Dermatitis, Allergic Contact , Dermatitis, Irritant , Military Medicine/methods , Allergens/adverse effects , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/immunology , Dermatitis, Allergic Contact/pathology , Dermatitis, Allergic Contact/therapy , Dermatitis, Irritant/diagnosis , Dermatitis, Irritant/immunology , Dermatitis, Irritant/pathology , Dermatitis, Irritant/therapy , HumansABSTRACT
Comprehensive investigation of 2620 patients with general somatic diseases revealed acute gastroduodenal erosions in 252 of them and chronic gastroduodenal erosions in 178 patients. Principal differences between clinical, endoscopic and morphological features of those two types of erosion due to etiological and pathogenetic character of their formation were established as the changes in the immune response, disorders in the protein and lipid metabolism. Almost 75% of chronic erosions correlated with circulation disorders, the diseases of hepatobiliary system and were their local morphological equivalents.
Subject(s)
Duodenitis/diagnosis , Gastritis/diagnosis , Peptic Ulcer/diagnosis , Adult , Biliary Tract Diseases/complications , Cardiovascular Diseases/complications , Duodenal Ulcer/diagnosis , Duodenal Ulcer/etiology , Duodenitis/etiology , Duodenoscopy , Female , Gastritis/etiology , Gastroscopy , Humans , Liver Diseases/complications , Male , Metabolic Diseases/complications , Middle Aged , Peptic Ulcer/etiology , Stomach Ulcer/diagnosis , Stomach Ulcer/etiologyABSTRACT
The article deals with peculiarities of allergic diseases (bronchial asthma, pre-asthma, pollinosis) in patients who were exposed to the factors of radiative, catastrophe. Screening--questionnaire was made on 381 patients who went through the Chernobyl disaster. 46 patients from this number who had various allergic diseases were chosen for specific diagnostics and immunological researches. A conclusion was made that critical systems of organism, and especially the immune systems had the major significance for the development and outcome of radiative injuries. The disorders in these systems contribute to the development of allergic diseases.
Subject(s)
Hypersensitivity/diagnosis , Occupational Exposure/adverse effects , Radioactive Pollutants/adverse effects , Accidents , Adolescent , Adult , Asthma/complications , Asthma/diagnosis , Female , Humans , Hypersensitivity/complications , Male , Middle Aged , Nuclear Reactors , Power Plants , Rhinitis, Allergic, Seasonal/complications , Rhinitis, Allergic, Seasonal/diagnosis , UkraineSubject(s)
Duodenal Ulcer/blood , Lymphocytes , Adult , Duodenal Ulcer/diagnosis , Female , Humans , Leukocyte Count , Lymphocytes/cytology , MaleABSTRACT
Leucocytes were studied in 112 patients with ulcer disease of the stomach in comparison with periods of existence of an ulcer defect of the gastric mucosa. Methods of statistical analysis allowed to establish that the peripheral blood shows phasic changes in the absolute content of the leucocytes and their forms, pathogenetically related to the course of the reparative process.
