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6.
Vopr Virusol ; (1): 79-81, 1978.
Article in Russian | MEDLINE | ID: mdl-347720

ABSTRACT

The results of the study of rimantadine effectiveness in a viral-bacterial infection in white mice caused by a mixture of influenza A2 virus (10 LD50) and hemolytic streptococcus group A (350 million bacteria). The drug showed no prophylactic or therapeutic effect in the mixed infection, whereas in influenza infection in the animals which served as a positive control rimantadine had marked antiviral activity (P less than 0.001). It is assumed that the lack of the drug effectiveness against the mixed infection is due to the formation in the animals of virus-microbe complexes which are conducive to an increase of infectious virus titers and virus resistance to various treatments.


Subject(s)
Adamantane/therapeutic use , Anti-Infective Agents/therapeutic use , Bridged-Ring Compounds/therapeutic use , Orthomyxoviridae Infections/drug therapy , Streptococcal Infections/drug therapy , Adamantane/analogs & derivatives , Animals , Anti-Bacterial Agents , Drug Evaluation , Influenza A virus , Male , Mice , Orthomyxoviridae Infections/complications , Streptococcal Infections/complications , Streptococcus pyogenes
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