[Characterization of enzymatic activity and structure of vesicles of human erythrocyte membranes]. / Kharakteristika fermentativnoi aktivnosti i struktury vezikul membran éritrotsitov cheloveka.

Enzymatic activity and structural peculiarities of human erythrocyte membranes obtained by different methods, are analyzed in the paper. Our studies have demonstrated different enzymatic activity of the preparations of right side- and inside-out vesicles of human erythrocyte membranes. Fluorescence probes of pyrene and ANS have shown that these membrane preparations have different physical characteristics of lipid and conformational properties of membrane proteins and differ in the composition of their protein-lipid ensembles.

[Cu(2+) complexes as inhibitors of free radical oxidation of lipids]. / Kompleksy Cu(2+)kak ingibitory svobodno-radikal'nogo okisleniia lipidov.

Cu(2+) complexes of chelate ligands have been studied for their effect on oxidation of rat blood plasma lipids, sphingomyelin, lecithin by the method of chemoluminescence. The studied Cu(2+) complexes have been shown to possess pro-oxidant and antioxidant properties depending on their concentration. Antioxidant activity of alpha-tocopherol, ionol (2,6-di(tert)-butyl-4-methylphenol) and Cu(2+) complexes by the lipid oxidation has been compared.

[Correction of disorders of phosphorus metabolism after operations on the abdominal organs]. / Korrektsiia narushenii obmena fosfora posle operatsii na organakh briushnoi polosti.

Hypophosphatemia and decreased content of ATP, 2,3-DPG in erythrocytes were found in 147 patients operated upon organs of the abdominal cavity. Hypophosphatemia was more pronounced after operations for ulcer disease of the stomach and duodenum, acute pancreatitis and commissural ileus. An intravenous injection of potassium dihydrogen phosphate++ prevents the development of hypophosphatemia and concomitant decrease of the content of nonorganic phosphorus, ATP, 2,3-DPG in erythrocytes and may improve the postoperative period in these patients.

[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma]. / Narushenie fosfornogo obmena i ego korrektsiia v ostrom periode tiazheloi cherepno-mozgovoi travmy.

Marked hypophosphatemia was discovered in 78 patients in the acute period of severe craniocerebral injury. It led to a decrease of the level of 2,3-diphosphoglycerate (2,3 DPG) and ATP in the red cells. The reduced ATP level in the red cells was one of the causes of reduced Ca2+ ATPase activity in their membranes. Intravenous infusion of 6.8% potassium dihydrophosphate solution prevented the development of hypophosphatemia and reduction of the content of 2,3 DPG and ATP in the red cells and Ca2+ ATPase activity in their membranes, which facilitated improvement in the course of acute posttraumatic period in patients with severe craniocerebral injury and decrease of mortality.

[The pharmacological correction of disorders of the oxygen transport function of the blood in peritonitis patients]. / Farmakologicheskaia korrektsiia narushenii kislorodtransportnoi funktsii krovi u bol'nykh peritonitom.

Arterial hypoxemia, decrease in non-organic phosphorus, 2,3-DPG, ATP erythrocyte levels and associated deterioration of O2 tissue supply have been observed in 106 patients with peritonitis. Intravenous administration of propranolol, potassium dihydrophosphate and inosine prevented a decrease in erythrocyte phosphate level, improved oxygen and energy tissue supply and reduced the duration of the patient stay in hospital.

[The correction of disorders of phosphorus and calcium metabolism in patients following surgery of the abdominal organs]. / Korrektsiia rasstroistva obmena fosfora i kal'tsiia u bol'nykh posle operatsii na organakh briushnoi polosti.

In 158 patients operated on the abdominal organs, hypophosphatemia and decrease in the content of ATP, 2,3-DPG in the erythrocytes were revealed. The level of protein-free calcium was increased in the plasma and erythrocytes. This evidenced in favour of the increased ionized calcium content. Intravenous administration of potassium dihydrophosphate prevented the development of hypophosphatemia and concomitant decrease in the content of inorganic phosphorus, ATP, 2,3-DPG in the erythrocytes.

[Causes, sequelae and possible ways of preventing hypophosphatemia in patients with cerebral ischemia]. / Prichiny, sledstviia i vozmozhnye puti preduprezhdeniia gipofosfa- temii u bol'nykh s tserebral'nymi disgemiiami.

Hypophosphatemia revealed in patients with acute disorders of cerebral circulation was one of the causes of a decrease of the content of 2,3-DPG, ATP in red blood cells and of a reduction of Ca2(+)-ATPase activity in red blood cell membranes. In the given group of patients, hypophosphatemia was provoked by complete parenteral feeding, hypocapnia and by loss of phosphorus with urine and congestive gastrointestinal contents.

[Characteristics of phosphorus metabolism in patients with acute disorders of cerebral circulation]. / Osobennosti obmena fosfora u bol'nykh s ostrymi narusheniiami mozgovogo krovoobrashcheniia.

The first 5 days of treatment of 98 patients with acute disorders of the cerebral blood circulation revealed hypophosphatemia and related reduction of the level of 2, 3 DPG, ATP in the erythrocytes. The causes of hypophosphatemia in these patients were absence of entrance of phosphorus to the body, its loss with the urine and gastrointestinal contents and hypocapnia. The possible ways of correction of these disorders are discussed.