ABSTRACT
The iron overload syndrome can be associated with various acquired states and hereditary factors. Hereditary hemochromatosis is the most common genetic disorder. Without therapeutic intervention the disease can lead to the development of life-threatening complications such as cirrhosis, hepatocellular carcinoma. The article presents data on pathogenesis, diagnosis and treatment of hereditary hemochromatosis. Own clinical observation is given.
Subject(s)
Hemochromatosis , Carcinoma, Hepatocellular/etiology , Hemochromatosis/complications , Hemochromatosis/diagnosis , Hemochromatosis/therapy , Humans , Liver Cirrhosis/etiology , Liver Neoplasms/etiology , SyndromeABSTRACT
In a structure of the cardio-vascular system diseases in Ukraine the part of chronical ischemia of the lower extremities tissues constitutes more than 20%. Due to diffuse affection of the distal parts of arterial bed it is impossible to succeed in performance of a direct" revascularization in 40% of patients. In 60-87% of such patients a severe ischemia of the lower extremities tissues occurs, causing the necessity of their high amputation performance on the hip level. The results of surgical treatment of 36 patients, suffering inoperable types of the peripheral arteries occlusion were analyzed. In 18 patients the algorithm of intraoperative ultrasound duplex scanning was applied, surgical interventions were performed using optimized procedures. As a second stage the PRP-therapy was conducted, since the second post-operative day all the patients have had performed the elaborated complex of physical exercises, directed on the shin and hip muscles strengthening. Optimization of the lower extremities indirect revascularization methods have permitted to increase the rate of the treatment positive results from 55.6 to 88.9%, to reduce the unsatisfactory results rate--from 44.4 to 11.1%. The PRP-therapy and complex of regular physical exercises conduction have promoted the VEGF content enhancement in the blood serum by 15.6%. malleolar-brachial index--by 28.9% in the patients, suffering occlusion of femoro-popliteo-tibial segment. PRP-concentrate constitutes a potent cell biological activator of the VEGF, improves metabolism and microcirculation in muscles and cells of the skin.
Subject(s)
Arterial Occlusive Diseases/therapy , Exercise Therapy/methods , Lower Extremity/blood supply , Platelet-Rich Plasma , Vascular Surgical Procedures/methods , Arterial Occlusive Diseases/diagnostic imaging , Arterial Occlusive Diseases/physiopathology , Arterial Occlusive Diseases/surgery , Blood Flow Velocity/physiology , Combined Modality Therapy , Female , Humans , Lower Extremity/diagnostic imaging , Lower Extremity/physiopathology , Lower Extremity/surgery , Male , Middle Aged , Treatment Outcome , UltrasonographyABSTRACT
The dynamics of the renin and angiotensin converting ferment activity and of the aldosterone concentration in the plasma of blood by healthy newborn full-term in the first week of the life after the birth was determined. The normative values of the studied indexes were obtained. The researches have shown the considerable functional tension of the renin-angiotensin-aldosterone system, that has a very important signification for optimal course of adaptation and anabolic processes by the children at the very beginning of the postnatal development.
