[Combined morphologic evaluation of the efficacy of progestin therapy of primary endometrial cancer]. / Kompleksnaia morfologicheskaia otsenka éffektivnosti progestinoterapii pervichnogo raka éndometriia.

A complex morphologic procedure for evaluating the effect of synthetic progestin treatment in 136 cases of primary endometrial cancer was analysed. Changes in structural and functional characteristics of tumor testifying to the elevated degree of cell differentiation were observed in 89.7 +/- 6.4 per cent of cases of well- and moderately-differentiated endometrial cancer. In glandular-solid cancer group, the response was registered in 52.6 +/- 11.5 per cent and manifested itself in tumor showing the same changes coupled with an increase in glandular structures, or developing squamous metaplasia in solid areas. Hormonal effects following hydroxyprogesterone capronate treatment were found in 81.8 +/- 11.6% of adenoacanthocarcinoma patients.