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Neurosci Lett ; 20(3): 307-12, 1980 Dec.
Article in English | MEDLINE | ID: mdl-6108539

ABSTRACT

Effects of Mg2+, L-glutamate (L-Glu) and L-glutamic acid diethylester (GDEE) on resting and evoked activities of the ampullae of Lorenzini were studied in marine skates (Raja clavata). Perfusion of the basal membrane with 10(-4)-10(-5) M L-Glu produced significant and reversible changes in resting firing rate depending on initial resting rate. When synaptic transmission was blocked by perfusion with elevated Mg2+, the resting activity was restored if L-Glu (10(-4)-10(-5) M) was added. GDEE (10(-3)-10(-4) M) blocked the synaptic transmission. The results are consistent with the view that L-Glu is the synaptic transmitter in the ampullae of Lorenzini of the skate.


Subject(s)
Fishes/physiology , Glutamates/physiology , Neurotransmitter Agents , Sensory Receptor Cells/physiology , Animals , Glutamates/pharmacology , In Vitro Techniques , Magnesium/pharmacology , Sensory Receptor Cells/drug effects , Synaptic Transmission/drug effects
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