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1.
Eur J Oncol Nurs ; 52: 101971, 2021 Jun.
Article in English | MEDLINE | ID: mdl-34022580

ABSTRACT

PURPOSE: Xerostomia is one of the multidimensional effects of cancer therapy that can impact on patients' quality of life. This study aims to evaluate the reliability and validity properties of the xerostomia questionnaire. METHODS: The data were retrieved from a randomized, interventional and longitudinal follow-up study of 72 head and neck cancer patients on active oral radiotherapy. Data were retrieved by the Xerostomia Questionnaire, the EORTC-QLQ C30 and EORT QLQ HN35. Data analyzes included intrinsic credibility of affinity Cronbach alpha factor, which is related to validity and cross-sectional validity. RESULTS: The Cronbach's alpha index of the Greek version of the questionnaire was high. Explicitly, the total scale of the questionnaire had an α = 0.97, and the individual dimensions - Degree of dryness and the quality of life had an alpha of 0.97 and 0.98 respectively. The xerostomia dimension of the questionnaire has a high positive correlation with QLQ C30 overall (r = 0.61, p < 0.001), and with the HN35 xerostomia dimension (r = 0.63, p < 0.001) which demonstrate its' concurrent validity. The dimensions of the xerostomia questionnaire were highly correlated with the EORTC-QLQ C30 dimensions which supports its' predictive validity. The level of xerostomia and the quality of life varied according to the level of pain of the patients (p < 0.001) that support the cross-sectional validity of the questionnaire. CONCLUSION: The Greek version of the xerostomia questionnaire is a reliable and valid tool for use in head and neck cancer patients on active oral radiotherapy.


Subject(s)
Quality of Life , Xerostomia , Cross-Sectional Studies , Follow-Up Studies , Humans , Psychometrics , Reproducibility of Results , Surveys and Questionnaires , Xerostomia/diagnosis
2.
J Nurs Meas ; 29(2): 317-333, 2021 Aug 01.
Article in English | MEDLINE | ID: mdl-33741726

ABSTRACT

BACKGROUND AND PURPOSE: Oral mucositis is one of the most common treatment-induced adverse side effects in head and neck cancer patients. The purpose was to evaluate the reliability and validity of the Greek version of the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer (OMWQ-HN). METHODS: The data were retrieved from 72 head and neck cancer patients who were undergoing oral radiotherapy as monotherapy or in combination with chemotherapy and surgery. Data analyses included internal consistency reliability, criterion related validity, and cross-sectional validity. RESULTS: The OMWQ-HN demonstrated good criterion validity. Strong correlations were observed between OMWQ-HN with EORTC QLQ-C30 and EORTC QLQ-H&N35 that showed good concurrent validity. The tool has a strong internal consistency index with α = .92. CONCLUSION: The Greek version of OMWQ-HN is a reliable and valid instrument that can be used for the assessment of oral mucositis in this context.


Subject(s)
Head and Neck Neoplasms/psychology , Head and Neck Neoplasms/radiotherapy , Psychometrics/standards , Quality of Life/psychology , Radiotherapy/adverse effects , Stomatitis/etiology , Stomatitis/psychology , Surveys and Questionnaires/standards , Adult , Aged , Cross-Sectional Studies , Female , Greece , Humans , Male , Middle Aged , Reproducibility of Results
3.
Eur J Oncol Nurs ; 34: 89-97, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29784145

ABSTRACT

PURPOSE: Radiation-induced oral mucositis is one of the main side effects during and after the treatment of head and neck cancer patients. The study was designed to provide evidence on the effectiveness of thyme honey on oral mucositis management. METHODS: This was a randomised controlled trial (RCT) with 72 head and neck cancer patients who were divided either to the intervention group (thyme honey rinses) or to the control group (saline rinses). Oral mucositis was assessed according to the Radiation Therapy Oncology Group (RTOC criteria), and assessments were performed weekly starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later. Additionally, the Oral Mucositis Weekly Questionnaire (OMWQ) was given at 4th week of radiotherapy, 1 month after the completion of radiotherapy and 6 months later. The ClinicalTrials.gov Identifier for this study is NCT01465308. This paper reports on the findings regarding thyme honey's effectiveness on oral mucositis. RESULTS: Generalized estimating equations revealed that patients in the intervention group were graded lower in the objective assessment of oral mucositis (p < 0,001), maintained their body weight (p < 0,001) and showed an improvement in their global health (p = 0.001) compared to the control group. Quality of life of the patients in the same group was also statistically significantly higher than that of the patients of the control group (p < 0,001). CONCLUSION: The study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis and quality of life in head and neck cancer patients.


Subject(s)
Head and Neck Neoplasms/radiotherapy , Honey , Plant Extracts/therapeutic use , Radiation Injuries/drug therapy , Radiotherapy/adverse effects , Stomatitis/drug therapy , Thymus Plant/chemistry , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Quality of Life , Radiation Injuries/etiology , Stomatitis/etiology , Surveys and Questionnaires
4.
Eur J Oncol Nurs ; 27: 1-8, 2017 Apr.
Article in English | MEDLINE | ID: mdl-28279391

ABSTRACT

PURPOSE: Radiation-induced xerostomia is one of the most common side effects that head and neck cancer patients experience during and after treatment. Despite the various methods for the prevention and treatment of radiation-induced xerostomia, it remains highly prevalent among patients treated for head and neck cancers negatively influencing their lives. The purpose of this study was to evaluate the effectiveness of thyme honey as a means for managing radiation-induced xerostomia. METHOD: This was a parallel randomised controlled trial with two equal arms, the experimental arm (thyme honey) and the control arm (saline). 72 head and neck cancer patients receiving radiotherapy or/and chemotherapy or/and surgery were recruited in a specialised cancer centre. Patients in both arms followed the same administration protocol with thyme honey and saline respectively. Identical assessments at baseline, 1 month and 6 months following completion of the intervention were performed in both arms including the National Cancer Institute (NCI) xerostomia scale and the Xerostomia Questionnaire (XQ) additionally to weekly oral clinical assessments. The ClinicalTrials.gov Identifier for this study is NCT01465308. RESULTS: Linear Mixed Models revealed the statistically significant effect of the intervention on xerostomia (F = 8.474 p < 0.001) and overall quality of life (F = 13.158 p < 0.001). Moreover, Generalised Estimating Equations revealed a statistically significant effect on strong and unbearable pain (F = 10.524 p < 0.001) and dysphagia (F = 4.525 p = 0.033). CONCLUSION: The study has demonstrated the safety and efficacy findings of Thyme honey in head and neck cancer patients for the management of treatment induced xerostomia.


Subject(s)
Head and Neck Neoplasms/complications , Head and Neck Neoplasms/radiotherapy , Honey , Radiotherapy/adverse effects , Thymus Plant/chemistry , Xerostomia/drug therapy , Xerostomia/etiology , Adult , Aged , Female , Humans , Male , Middle Aged , Quality of Life , Surveys and Questionnaires
5.
Anticancer Res ; 32(2): 657-64, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22287759

ABSTRACT

AIM: The main objective was to delineate the rates and clinical course of sexual function and depression in cancer patients undergoing radiotherapy. PATIENTS AND METHODS: Forty-eight male and 90 female radiotherapy-naive outpatients with breast or pelvic cancer completed the International Index of Erectile Function (IIEF) or the Female Sexual Function Index (FSFI), and the Hamilton Depression Scale (HDS) prior to (phase 1), at the end of (phase 2) and 12 months after radiotherapy (phase 3). RESULTS: Overall, the majority of patients (93.8% of males and 80% of females) experienced intense sexual dysfunction. At presentation, males reported severe erectile dysfunction that was significantly associated with age. However, only in sexual desire was the difference between baseline and phase 3 significant. In females, an improvement was observed in all parameters of FSFI between phase 1 and 3. Females with stage III disease achieved lower scores in almost all parameters of FSFI than those with stage II. Finally, although a quarter of patients reported elevated depression scores, depression was not related to sexual function. CONCLUSION: A significant proportion of cancer patients experience intense levels of sexual dysfunction and depression throughout radiotherapy and the subsequent year. Pelvic radiotherapy affected sexual function to a higher degree than did breast radiotherapy.


Subject(s)
Breast Neoplasms/radiotherapy , Pelvic Neoplasms/radiotherapy , Sexual Dysfunction, Physiological/etiology , Sexual Dysfunctions, Psychological/etiology , Adult , Aged , Aged, 80 and over , Breast Neoplasms/physiopathology , Breast Neoplasms/psychology , Depression/etiology , Depression/psychology , Erectile Dysfunction/etiology , Erectile Dysfunction/psychology , Female , Humans , Male , Middle Aged , Pelvic Neoplasms/physiopathology , Pelvic Neoplasms/psychology , Radiation Injuries/etiology , Radiation Injuries/psychology , Radiotherapy/adverse effects , Sexual Dysfunction, Physiological/psychology , Sexual Dysfunctions, Psychological/psychology
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