Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Publication year range
1.
Vet Comp Oncol ; 14 Suppl 1: 8-20, 2016 Aug.
Article in English | MEDLINE | ID: mdl-24410724

ABSTRACT

This study describes epidemiologic, clinical, macro- and microscopic tumour characteristics and outcome in 97 cats with subcutaneous lymphoma, an uncommon variant of feline extranodal lymphoma. Middle-aged (median 11 years), male (60.8%), Domestic Shorthair cats (89.7%) were commonly affected. Most tumours presented as a painless, firm, subcutaneous nodule or mass, with predilection to the lateral thoracic or abdominal wall, and the interscapular region. Deep subcutaneous invasion with extension into superficial or underlying tissues, extensive central areas of necrosis and peripheral inflammation were characteristic histopathological findings. Prevalence of retroviral infection was low. Local relapses after therapy were common (43.5%), and 32.2% had distant involvement later in course. Median overall survival was 148 days. Subcutaneous lymphoma should be considered a rare but important differential diagnosis for a subcutaneous mass in cats. Tumours show an aggressive biological behaviour. Treatment options including prognosis should be investigated in further studies.


Subject(s)
Cat Diseases/pathology , Lymphoma, Non-Hodgkin/veterinary , Skin Neoplasms/veterinary , Subcutaneous Tissue/pathology , Animals , Antineoplastic Combined Chemotherapy Protocols , Cat Diseases/drug therapy , Cat Diseases/epidemiology , Cats , Databases, Factual , Diagnosis, Differential , Female , Germany/epidemiology , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/epidemiology , Lymphoma, Non-Hodgkin/pathology , Male , Neoplasm Recurrence, Local , Skin Neoplasms/drug therapy , Skin Neoplasms/epidemiology , Skin Neoplasms/pathology , Survival Analysis
2.
Vet Pathol ; 49(5): 846-51, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22308233

ABSTRACT

Cutaneous lymphoma is a common skin neoplasm of pet rabbits in Europe but is rarely reported in pet rabbits in North America. These neoplasms have not been previously characterized, nor has the cause for the apparent predilection for cutaneous lymphoma in European pet rabbits compared with North American pet rabbits been investigated. In this retrospective study, the authors morphologically and immunohistochemically characterized 25 cutaneous lymphomas in European pet rabbits according to the World Health Organization classification. Tumors were classified as diffuse large B cell lymphomas, with 14 lymphomas exhibiting a centroblastic/centrocytic subtype and 11 tumors exhibiting a T cell-rich B cell subtype. To investigate a potential viral etiology of these lymphomas, 3 diffuse large B cell and 3 T cell-rich B cell lymphomas were evaluated by polymerase chain reaction for retroviral and herpesviral genes. Neither virus was detected. In contrast to other domestic animals, cutaneous lymphomas in European pet rabbits were highly pleomorphic and frequently contained multinucleated giant cells. Unexpectedly, the second most common subtype was T cell-rich B cell lymphoma, a subtype that is rare in species other than horses. Based on a limited number of samples, there was no support for a viral etiology that would explain the higher incidence of lymphoma in European pet rabbits compared with American pet rabbits. Further investigation into genetic and extrinsic factors associated with the development of these tumors is warranted.


Subject(s)
Lymphoma, B-Cell/veterinary , Lymphoma, Large B-Cell, Diffuse/veterinary , Lymphoma, T-Cell, Cutaneous/veterinary , Rabbits , Skin Neoplasms/veterinary , Animals , CD79 Antigens/metabolism , Europe , Female , Immunohistochemistry/veterinary , Immunophenotyping/veterinary , Lymphoma, B-Cell/classification , Lymphoma, B-Cell/pathology , Lymphoma, Large B-Cell, Diffuse/classification , Lymphoma, Large B-Cell, Diffuse/pathology , Lymphoma, T-Cell, Cutaneous/classification , Lymphoma, T-Cell, Cutaneous/pathology , Male , Retrospective Studies , Skin Neoplasms/classification , Skin Neoplasms/pathology
3.
J Comp Pathol ; 146(2-3): 152-9, 2012.
Article in English | MEDLINE | ID: mdl-21783199

ABSTRACT

Olfactory neuroblastoma (ONB) was identified in 13 dogs and nine cats. The tumours were subjected to microscopical examination and were graded using a human pathological grading system. In the canine and feline tumours there was more necrosis and higher mitotic activity (mitotic index and Ki67 labelling index) than reported in human ONB. Rosettes were a common feature of feline ONBs. A significant correlation was observed between the histological grade and the Ki67 labelling index. The histopathological diagnosis of ONB was confirmed immunohistochemically by demonstration of the neuronal marker neuron-specific enolase (NSE). Two other neuron-specific antibodies specific for microtubule-associated protein-2 (MAP-2) and neuronal nuclei antigen (NeuN) were evaluated. MAP-2 expression proved to have higher specificity than labelling for NSE. NeuN expression was less sensitive and of limited practical value.


Subject(s)
Cat Diseases/pathology , Dog Diseases/pathology , Esthesioneuroblastoma, Olfactory/veterinary , Nasal Cavity , Nose Neoplasms/veterinary , Animals , Cat Diseases/metabolism , Cats , Dog Diseases/metabolism , Dogs , Esthesioneuroblastoma, Olfactory/metabolism , Esthesioneuroblastoma, Olfactory/pathology , Immunohistochemistry , Microtubule-Associated Proteins/metabolism , Mitotic Index , Nasal Cavity/metabolism , Nasal Cavity/pathology , Necrosis/metabolism , Necrosis/pathology , Necrosis/veterinary , Nose Neoplasms/metabolism , Nose Neoplasms/pathology , Phosphopyruvate Hydratase/metabolism
4.
Vet Pathol ; 44(5): 579-88, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17846230

ABSTRACT

Over a 16-year period, 190 tumors and tumorlike lesions from 179 pet rabbits were submitted for histopathologic examination. A total of 23 different tumor types and 1 tumorlike lesion were diagnosed. The most common diagnoses were trichoblastoma, collagenous hamartoma, and Shope fibroma. Viral-induced tumors were Shope fibroma (19) and Shope papilloma (2). Common nonviral epithelial tumors included trichoblastoma (59), squamous cell carcinoma (5), squamous papilloma (4), trichoepithelioma (3), and apocrine carcinoma (3). Common mesenchymal tumors were lipoma (10), liposarcoma (3), myxosarcoma (9), malignant peripheral nerve sheath tumor (8), fibrosarcoma (7), and leiomyosarcoma (4). Malignant melanoma was diagnosed in 8 rabbits. Collagenous hamartomas were diagnosed in 26 rabbits. Mesenchymal proliferations occurred significantly more often in male rabbits than in females. Collagenous hamartomas and myxosarcomas occurred exclusively in male animals, and 3 rabbits had multiple collagenous hamartomas. Immunohistochemistry was applied in cases in which a definite diagnosis could not be reached on hematoxylin and eosin slides. Follow-up information was received in 19 cases. Carcinomas recurred (2 of 3) or metastasized (1 of 3), whereas sarcomas frequently recurred (7 of 12). One malignant melanoma (1 of 3) and one poorly differentiated round cell neoplasm recurred (1 of 1). This is the first comprehensive retrospective analysis on skin neoplasia in pet rabbits.


Subject(s)
Rabbits , Skin Neoplasms/veterinary , Adenoma/pathology , Adenoma/veterinary , Animals , Biopsy/veterinary , Carcinoma/pathology , Carcinoma/veterinary , Female , Hamartoma/pathology , Hamartoma/veterinary , Lipoma/pathology , Lipoma/veterinary , Lymphoma/pathology , Lymphoma/veterinary , Male , Melanoma/pathology , Melanoma/veterinary , Retrospective Studies , Sarcoma/pathology , Sarcoma/veterinary , Skin Neoplasms/classification , Skin Neoplasms/pathology , Tumor Virus Infections/veterinary
6.
Schweiz Arch Tierheilkd ; 144(9): 467-72, 2002 Sep.
Article in German | MEDLINE | ID: mdl-12677685

ABSTRACT

A case of bovine abortion was for the first time in Switzerland diagnosed by immunohistochemistry PCR (16S rRNA, ompA) and gene sequence analysis to be caused by Chlamydia psittaci. A possible occurence of further cases has to be investigated. Based on the existence of several methods with very different sensitivity and specificity to diagnose chlamydia it is suggested that at least two verified diagnostic tools should be used to diagnose an involvement of chlamydia in bovine abortion.


Subject(s)
Abortion, Veterinary/microbiology , Cattle Diseases/microbiology , Psittacosis/veterinary , Animals , Cattle , Cattle Diseases/diagnosis , Chlamydophila psittaci/immunology , Chlamydophila psittaci/isolation & purification , Female , Immunohistochemistry/veterinary , Polymerase Chain Reaction/veterinary , Pregnancy , Psittacosis/complications , Psittacosis/diagnosis , RNA, Ribosomal, 16S/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...