Low Back Pain: A Biomechanical Rationale Based on "Patterns" of Disc Degeneration.

STUDY DESIGN: A nonlinear finite element study of a lumbar spine with different "patterns" of multilevel intervertebral disc degeneration. OBJECTIVE: To determine how different patterns of multilevel disc degeneration influence the biomechanical behavior of the lumbar spine. SUMMARY OF BACKGROUND DATA: Because of the complex etiology of low back pain, it is often difficult to identify the specific factors that contribute to the symptoms of a particular patient. Disc degeneration is associated with the development of low back pain, but its presence is not always synonymous with symptoms. However, studies have suggested that "patterns" of disc degeneration may provide insight into such pain generation rather than the overall presence of degenerative changes. Specifically, individuals with contiguous multilevel disc degeneration have been shown to exhibit higher presence and severity of low back pain than patients with skipped-level disc degeneration (i.e., healthy discs located in between degenerated discs). METHODS: In this study, the biomechanical differences between these patterns were analyzed using a nonlinear finite element model of the lumbar spine. Thirteen separate "patterns" of disc degeneration were evaluated using the model and simulated under normal physiological loading conditions in each of the primary modes of spinal motion. RESULTS: The results showed that stresses and forces of the surrounding ligaments, facets, and pedicles at certain vertebral levels of the spine were generally lower in skipped-level disc degeneration cases than in the contiguous multilevel disc degenerations cases even when the skipped level contained more degenerated discs. CONCLUSION: To our knowledge, this is the first study to illustrate the biomechanics of specific patterns of disc degeneration of the lumbar spine. Using a multilevel disc degeneration model, our study provides insights as to why various patterns of disc degeneration throughout the lumbar spine may affect motion and soft tissue structures as well that may have bearing in the clinical pathway of pain generation. LEVEL OF EVIDENCE: N/A.

A damage model for the percutaneous triple hemisection technique for tendo-achilles lengthening.

A full understanding of the mechanisms of action in the percutaneous triple hemisection technique for tendo-achilles lengthening has yet to be acquired and therefore, an accurate prediction of the amount of lengthening that occurs is difficult to make. The purpose of this research was to develop a phenomenological damage model that utilizes both matrix and fiber damage and replicates the observed behavior of the tendon tissue during the lengthening process. Matrix damage was triggered and evolved relative to shear strain and the fiber damage was triggered and evolved relative to fiber stretch. Three examples are given to show the effectiveness of the model. Implementation of the damage model provides a tool for studying this common procedure, and may allow for numerical investigation of alternative surgical approaches that could reduce the incidence rates of severe over-lengthening.

Failure modes and fracture toughness in partially torn ligaments and tendons.

Ligaments and tendons are commonly torn during injury, yet the likelihood that untreated initial tears could lead to further tearing or even full rupture has proven challenging to predict. In this work, porcine Achilles tendon and human anterior longitudinal ligament samples were tested using both standard fracture toughness methods and complex loading conditions. Failure modes for each of 14 distinct testing cases were evaluated using a total of 131 soft tissue tests. Results showed that these soft tissues were able to completely resist any further crack propagation of an initial tear, regardless of fiber orientation or applied loading condition. Consequently, the major concern for patients with tendon or ligament tears is likely not reduction in ultimate tissue strength due to stress risers at the tip of the tear, but rather a question of whether or not the remaining cross-section is large enough to support the anticipated loading.

Changes in vertebral strain energy correlate with increased presence of Schmorl's nodes in multi-level lumbar disk degeneration.

Patients with skipped-level disk degeneration (SLDD) were recently reported as having a higher prevalence of Schmorl's nodes than patients with contiguous multi-level disk degeneration (CMDD). Fourteen versions of a nonlinear finite element model of a lumbar spine, representing different patterns of single and multi-level disk degeneration, were simulated under physiological loading. Results show that vertebral strain energy is a possible predictor in the development of Schmorl's nodes. The analysis also shows evidence that the development of Schmorl's nodes may be highly dependent on the location of the degeneration disk, with a higher prevalence at superior levels of the lumbar spine.

Biomechanical implications of lumbar spinal ligament transection.

Many lumbar spine surgeries either intentionally or inadvertently damage or transect spinal ligaments. The purpose of this work was to quantify the previously unknown biomechanical consequences of isolated spinal ligament transection on the remaining spinal ligaments (stress transfer), vertebrae (bone remodelling stimulus) and intervertebral discs (disc pressure) of the lumbar spine. A finite element model of the full lumbar spine was developed and validated against experimental data and tested in the primary modes of spinal motion in the intact condition. Once a ligament was removed, stress increased in the remaining spinal ligaments and changes occurred in vertebral strain energy, but disc pressure remained similar. All major biomechanical changes occurred at the same spinal level as the transected ligament, with minor changes at adjacent levels. This work demonstrates that iatrogenic damage to spinal ligaments disturbs the load sharing within the spinal ligament network and may induce significant clinically relevant changes in the spinal motion segment.

Thoracolumbar spinal ligaments exhibit negative and transverse pre-strain.

The present work represents the first reported bi-axial spinal ligament pre-strain data for the thoracic and lumbar spine. Ligament pre-strain (in-situ strain) is known to significantly alter joint biomechanics. However, there is currently a lack of comprehensive data with regards to spinal ligament pre-strain. The current work determined the pre-strain of 71 spinal ligaments (30 anterior longitudinal ligaments, 27 supraspinous ligaments and 14 interspinous ligaments). The interspinous ligament and the anterior longitudinal ligament exhibited bi-axial pre-strain distributions, demonstrating they are not uniaxial structures. The supraspinous ligament frequently exhibited large amounts of negative pre-strain or laxity suggesting it makes no mechanical contribution to spinal stability near the neutral posture. Upon implementing multi-axial pre-strain results into a finite element model of the lumbar spine, large differences in spinal biomechanics were observed. These results demonstrate the necessity of accounting for ligament pre-strain in biomechanical models. In addition, the authors present a unique experimental method for obtaining ligament pre-strain that presents a number of advantages when compared to standard techniques.