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Med Klin Intensivmed Notfmed ; 112(2): 145-148, 2017 Mar.
Article in German | MEDLINE | ID: mdl-27221094

ABSTRACT

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are new antidiabetic drugs that regulate blood glucose levels by increasing urinary glucose excretion. In May 2015, the U.S. Food and Drug Administration (FDA) issued a warning that SGLT2 inhibitors may lead to ketoacidosis. In this report, we describe a case of life-threatening euglycemic ketoacidosis associated with SGLT2 inhibition and evaluate possible mechanisms and triggers.


Subject(s)
Blood Glucose/metabolism , Diabetes Mellitus, Type 2/blood , Diabetes Mellitus, Type 2/drug therapy , Diabetic Ketoacidosis/blood , Diabetic Ketoacidosis/chemically induced , Hypoglycemic Agents/adverse effects , Hypoglycemic Agents/therapeutic use , Sodium-Glucose Transporter 2 Inhibitors , Benzhydryl Compounds/adverse effects , Benzhydryl Compounds/therapeutic use , Combined Modality Therapy , Diabetic Ketoacidosis/therapy , Drug Therapy, Combination , Glucosides/adverse effects , Glucosides/therapeutic use , Humans , Insulin Glargine/adverse effects , Insulin Glargine/therapeutic use , Male , Metformin/adverse effects , Metformin/therapeutic use , Middle Aged , Risk Factors , Sodium-Glucose Transporter 2
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