ABSTRACT
A 12-year-old male child born of non-consanguineous parents presented with multiple skin lesions, hoarseness of voice, and episodes of epilepsy since early childhood. The findings of characteristic beaded eyelid margins, patchy alopecia of the scalp, hoarseness of voice, and epilepsy were consistent with a rare clinical diagnosis, lipoid proteinosis. Skin biopsies obtained from representative skin lesions were subjected to histology and electron microscopy. Light microscopy demonstrated PAS-positive diastase-resistant material in the papillary dermis of skin. Ultrastructure revealed granulo-filamentary aspect of the accumulated material. Although this rare autosomal recessive disorder has been described in the literature, its occurrence is rare in India.
Subject(s)
Alopecia/etiology , Epilepsy/etiology , Hoarseness/etiology , Lipoid Proteinosis of Urbach and Wiethe/complications , Lipoid Proteinosis of Urbach and Wiethe/pathology , Skin/pathology , Tongue/pathology , Alopecia/pathology , Child , Head , Humans , India , Male , Neck , Skin/ultrastructureABSTRACT
Out of 23808, sera screened for syphilis by VDRL tests from antenatal cases, 1155 were reactive, giving an incidence of 4.85%. This has been compared with the incidence of reactive ,sera for syphilis in antenatal cases by various other workers. We have compared 300 sera with various reactivity by VDRL test with KVT and found only 2 false positive and 57 inconclusive, thereby indicating need to have specific tests. There was-good correlation between VDRL and KVT, but VDRL was more sensitive, whereas KVT was more specific. Various serological tests for screening syphilis have been discussed in brief and ultimately concluded that VDRL is the best screening test.
