[The persistence of pathogens and its immunepathological consequences]. / Die Persistenz pathogener Erreger und ihre immunpathologischen Folgen.

In principle the persistence of pathogens is favored by disturbances of the interplay between specific humoral and cellular defence mechanisms in the particular individual characteristic. Clinical secondary reactions in persistence of infection are in many cases not characterized by the infection as such but more decisively by the "terrain" which a particular organism encounters. This terrain is characterized by immunopathological secondary reactions which now become in turn the basis of the clinical secondary disease. In the individual case the manifestations are due to: acquired disturbances of immunotolerance; formation of neoantigens or induced autoimmune reactions; frequent immune complex reactions due to infectious or secondary antigens with corresponding antibody formation and complement activation.

[Inflammatory diseases of the vessels. Clinical aspects, immunopathology, characteristic features of therapy (author's transl)]. / Entzündliche Gefässerkrankungen. Klinik, Immunpathologie, Grundzüge der Therapie.

Arterial obstructive diseases become manifest principally in the great peripheral vessels, visceral symptoms are rare. In the overwhelming majority of inflammatory vascular processes changes in the small arteries are impressive, visceral symptoms are common, in many cases the rule, peripheral occlusive syndromes are exceptions, although possible, and then prognostically especially serious in the individual case. The diagnosis of such vascular processes can be extraordinarily difficult if there is systemic spread because of the great variety of symptoms, and in the individual case may be almost impossible. Principles of classification should contribute to the facilitation of necessary clinical differentiation and lead to the proper therapeutic indication of the fundamental process. But they should also serve for the understanding of those inflammatory vascular diseases whose special position is based on the new scientific knowledge of immunopathology.