ABSTRACT
85 patients with migraine without aura and 20 healthy individuals were examined between the attacks, before the attack, during and after it (1-2 days). The examination included clinical-neurological analysis; psychological Spilberger's and Beck's tests, scale of alexithymia and complex algesic questionnaire; recording of the conditional negative wave; determination of nociceptive flexor reflex; recording of trigeminal evoked potentials; spectral analysis of the heart's rhythms; polysomnographic study. Psychophysiologic pattern characteristic for all the patients was established. Psychological and neurophysiological parameters changed synchronously in the periods before the attack, during and after it. Before the migraineous attack a specific pathologic integration increased and presented maximally (the activity of antinociceptive system weakens anxiety increased, tension of catecholaminergic systems grew, hyperactivity in trigeninal sphere elevated, tolerance to the pain decreased). A clear tendency to the reversibility of these changes was observed after an attack. A dynamics revealed in the psychophysiological pattern could serve as a predictor of a migraineous attack and open some perspectives for prophylaxis of the algesic attack.
Subject(s)
Migraine Disorders/diagnosis , Migraine Disorders/physiopathology , Anxiety/psychology , Catecholamines/metabolism , Evoked Potentials/physiology , Humans , Migraine Disorders/metabolism , Polysomnography , Severity of Illness Index , Sleep, REM/physiology , Surveys and Questionnaires , Trigeminal Nerve/physiologyABSTRACT
The effectiveness of caffetin, combined analgetic drug, was estimated in treatment of acute cervicalgia and lumbar ischialgia (1 tablet 3 times daily during 10 days). Both clinical and psychological parameters were analysed. Caffetin had pronounced analgetic effect which was observed on the 2-3d day of drug application. Meanwhile there was improvement of clinical and psychological parameters, namely: relaxation of the muscles, decrease of either tension symptoms or of the levels of anxiety and depression as well as improvement of quality of life. The patients well tolerated caffetin administration without any side effects. There were no negative consequences of interaction of caffetin with other drugs (vascular, psychotropic). The conclusion was drawn about safety and effectiveness of caffetin for alleviation of acute pains in patients with myofascial, myotonic and radicular syndromes of different origin.
