ABSTRACT
The aim of our studies was to create diagnostically informative criteria of hematologic and biochemical analyses and their combinations as well as to establish relation between Chlamidia Pneumoniae A and atherosclerosis. This is to be done for the purpose of establishing the entire pathogenesis carotid and coronary atherosclerosis and inflammation. The investigation of Chlamidia Pneumoniae infection in proved to be a possible risk factor for the carotid atherosclerosis developed in adults that makes the course of atherosclerosis heavier. As a result of the atherosclerotic process, changes in the blood laboratory parameters were expressed more cases of pneumonia in the children.
Subject(s)
Atherosclerosis/microbiology , Atherosclerosis/pathology , Chlamydia Infections/complications , Chlamydia/isolation & purification , Antibodies, Bacterial/blood , Aorta, Abdominal/diagnostic imaging , Aorta, Abdominal/microbiology , Aorta, Abdominal/pathology , Atherosclerosis/blood , Blood Cell Count , Blood Chemical Analysis , Carotid Arteries/diagnostic imaging , Carotid Arteries/microbiology , Carotid Arteries/pathology , Chlamydia/immunology , Chlamydia Infections/immunology , Female , Humans , Male , Middle Aged , UltrasonographyABSTRACT
It has been established positive correlation of the degree of stenosis and intima-media thickness of carotid arteries with the following biochemical parameters: total cholesterol, LDL cholesterol, Apo-B, Lp(a), triglycerides, hs-C-reactive protein(CRP), interleukines (IL-1beta and IL-6), fibrinogen, D-dimers. Negative correlation was stated with respect to HDL cholesterol, Apo-A-1, protein C. Relation between the parameters of the blood lipid spectre, proteins and mediators of inflammation as well as those of hemostasis enables us to approach pathophysiological mechanisms of carotid atherosclerosis, define the processes of inflammation and atherosclerosis.
Subject(s)
Carotid Artery Diseases/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Prothrombin/metabolism , Thromboplastin/metabolism , Carotid Artery Diseases/diagnosis , Carotid Artery Diseases/immunology , Carotid Stenosis/blood , Carotid Stenosis/diagnosis , Carotid Stenosis/immunology , Female , Humans , Interleukin-1beta/immunology , Interleukin-6/immunology , Male , Middle AgedABSTRACT
Chemotherapy is known to raise the risk of developing thrombotic complications. The aim of our work is to study the system of hemostasis in patients with the lung cancer under chemotherapy treatment. 61 patients were examined (40 men, 21 women) between the ages of 32 and 75 years (the principal group). Chemotherapy was prescribed to 52 patients with the lung cancer considered as non-operable ones, and to 9 patients who refused surgical treatment. Chemotherapy applied to the patients was done by the conventional scheme. The treatment has been conducted from 16 to 20 days.Thrombocytic-vascular hemostasis, plasmatic hemostasis, physiological anticoagulant activity, the blood fibrinolytic activity, markers of intravascular coagulation of the blood and those of fibrinolysis, were studied. The depletion of compensatory mechanisms at all segments of hemostasis in non-operable patients was revealed. The type of reaction points at an oppressive effect of chemodrugs on the hemostasis system and the increase of the risk of development thrombotic complications in those patients.
Subject(s)
Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Blood Platelets/drug effects , Hemostasis/drug effects , Lung Neoplasms/drug therapy , Adult , Aged , Female , Humans , Male , Middle Aged , Neoplasm StagingABSTRACT
During last decades significant attention has been paid to the increase of protozoal infections including leishmaniasis. The management of this disease is rather problematic. Significant increase of cases of this disease was observed in Georgia as well. The problem of visceral leishmaniasis is very important nowadays. According to references and our clinical experience patients with visceral leishmaniasis are predisposed to bleeding. The objective of our study was the assessment of functional status of hemostasis in patients with visceral leishmaniasis. We have studied the intravascular activation markers of blood coagulation -- the soluble fibrin-monomeric complexes (SFMC) and fibrinogen/fibrin degradation products (D-dimer) in order to reveal the disorders of hemocoagulation. SFMC and D-dimer we studied in 45 patients with visceral leishmaniasis before and after treatment (with 20-25 day intervals). One patient with severe generalized bleeding died within 72 hours of admission. SFMC measurements were conducted by the orthophenantroline test (Renam, Russia). D-dimer level was measured using FDP-Slidex Direct kit (Bio-Meriou, France). Especially high levels of SFMC and D-dimer have been revealed in cases of severe form of visceral leishmaniasis. SFMC level was increased by 80% (p=0,003), and D-dimer level by 95,6% (p=0,023). There was correlation between numbers of platelets and intravascular blood coagulation markers. Investigation of SFMC and D-dimer showed that in case of visceral leishmaniasis activation of intravascular coagulation takes place, particularly during the severe forms of the disease. Study of these markers is of the diagnostic and prognostic importance and for the initiation of treatment at an early stage of infection, which may potentially avoid the possibility of developing an uncompensated DIC.
