[The characteristics of protein p53 expression in the mucosal epithelium of the large intestine affected by polyps and cancer]. / Osoblyvosti ekspresiï bilka p53 v epiteliï slyzovoï obolonky tovstoï kyshky, vrazhenoï polipamy ta rakom.

The direct dependence between p53 expression in epithelial cells and the level of morphological malignant neoplasm was established as the result of investigation of expression of this biomolecular marker in 12 polyps and 35 colorectal cancer. It was shown that family cancer syndrome 1 type was observed in pedigrees of majority patients with p53 positive cancers.

[The morphogenesis of cancer of the prostate (immunohistochemical research)]. / Morfohenez raku peredmikhurovoï zalozy (imunohistokhimichne doslidzhennia).

With the purpose of establishing morphogenetic features of precancer and early cancer of the prostate gland a comparative immunomorphological evaluation was done of the prostate tumor markers (PAP, PSA, PCNA, and 34 beta E12). Due emphasis is given to the part the basal cell dysplasia plays in morphogenesis of prostatic cancer. The precancer lesions of the prostate include atypical adenomatous hyperplasia, grade I and II prostatic intraepithelial neoplasia (PIN). Grade III prostatic intraepithelial neoplasm is cancer in situ, or uninfiltrative (unpalpable) cancer of the prostate. PIN patients are at high risk for subsequent development of invasive prostatic carcinoma.