[Problems of designing cardiac monitoring systems]. / Problemy proektirovaniia kardiomonitornykh sistem.

The paper considers one of the ways of solving the problems arising from the design of up-to-date monitoring systems. It describes a Karmon 01M multifunctional fixed monitor manufactured by SEM (Systems of Electronics and Medicine), which may include as many as three randomly chosen modules and replace software for new versions.

[Oxidative modification of cytochrome P-450 during its function. II. Study of the mechanism of cytochrome P-450 LM2 inactivation in a soluble reconstructed monooxygenase system]. / Okislitel'naia modifikatsiia tsitokhorma P-450 pri ego rabote. II. Issledovanie mekhanizma inaktivatsii tsitokhroma P-450 LM2 v rastvorimoi rekonstruirovannoi monooksigenaznoi sisteme.

Inactivation of cytochrome P-450 LM2 induced by hydrogen peroxide formed in the active site of the enzyme was studied. Catalase did not protect cytochrome P-450 LM2 from inactivation during its operation in a soluble reconstituted system. The hemoprotein inactivation in this system was found to depend on the ratio of hemo- to flavoproteins. It was demonstrated that cytochrome P-450 LM2 inactivation during catalysis is accompanied by cleavage of the hemoprotein molecule. It is probable that this fact plays a key role in regulation of enzyme decay.