[The comparative characteristic of immune status of males with bacterial inflammatory urogenital pathology of different etiology in the city of Orenburg].

The article discusses presence of typical characteristics of parameters of system immunity under gonococcal and nonspecific uretroprostatitis and diagnostic value of these indicators. The reliable differences of immunologic indicators in patients with gonorrhea are established as compared to patients with nonspecific bacterial uretroprostatitis. The study established in peripheral blood the reliable decrease of level of leukocytes, relative amount of monocytes, phagocyte index, functional reserve of leukocytes at the expense of spontaneous and stimulated NBT test, IgA, sIgA. On the contrary, the study detected increasing of level of IgM and lactoferrin in patients with gonorrhea as compared to corresponding indicators in patients nonspecific infections. Under gonorrhea, the largest deviation of indicators from standard values was established for lactoferrin. The detected differences of immunologic parameters can be used as differentiating markers of nonspecific and gonococcal uretroprostatitis and criteria of effectiveness of immune correction.

[Risk factors for violations of the fertility in men living in urban areas].

The immunocytokine status of the reproductive tract was evaluated in men with different forms of gonorrhea, who lived in the urbanized areas of the Orenburg Region. The typical form of gonorrhea, which is a risk for infertility, is accompanied by the reduced levels of lysozyme and IL-10 and the increase content of lactoferrin and proinflammatory cytokines, such as IL-1, Ibeta-6, and IL-8 in the ejaculate.

[Characteristics of associated microflora of ejaculate from males with gonococcal infections].

Species composition and biological properties of aerobic and anaerobic microflora from an ejaculate from males with acute and chronic gonococcal infection and from healthy men were studied. Patients with gonococcal infection were shown to present quantitative and qualitative changes in microbiocenosis of the reproductive tract. Patients with acute gonorrhea displayed decreased species diversity in contrast to healthy persons, while different species of associated with gonococci microbes with high persistent potential, were cultured in patients suffering from a chronic form of infection. The role of revealed pathological biocenosis patterns in developing chronic infection as well as postgonorrheal gonococci-free urethritis is discussed.

[The suppressive action of a magnetic-laser ray and of an electrolytic solution of sodium hypochlorite on the factors of causative agent persistence]. / Podavliaiushchee deistvie magnitno-lazernogo lucha i élektroliznogo rastvora gipokhlorita natriia na faktory persistentsii vozbuditelia.

The suppressive action of a magnet-laser ray and electrolyzed sodium hypochlorite solution on the persistence factors (antilysozyme, "anti-interferon") of Staphylococcus aureus and Neisseria gonorrhoeae is shown. The optimum conditions (time, dose, concentration) for the regulation of the persistence properties of the pathogens has been determined. The use of physicochemical factors in the proposed parameters has been shown to be effective for the therapy of purulent inflammatory diseases and the sanitation of S.aureus carriers.

[The antilysozyme activity of the causative agent in the diagnosis and prognosis of the course of gonococcal infection]. / Antilizotsimnaia aktivnost' vozbuditelia v diagnostike i prognozirovanii techeniia gonokokkovoi infektsii.

Differences in the frequency and level of antilysozyme activity in Neisseria gonorrhoeae cultures isolated from patients with different forms and stages of gonococcal infection were revealed. The possibility of using the antilysozyme sign of N. gonorrhoeae for the differential diagnostics of the clinical forms of this infection and for prognosticating the chronization of the inflammatory process in newly infected patients and in cases of relapses in chronic gonorrhea patients.