Subject(s)
Burns/therapy , Infrared Rays/therapeutic use , Laser Therapy , Wound Healing/radiation effects , Animals , Burns/immunology , Burns/pathology , Chronic Disease , Disease Models, Animal , Hot Temperature , Physical Stimulation , Rabbits , Skin Physiological Phenomena/immunology , Skin Physiological Phenomena/radiation effects , Wound Healing/immunologyABSTRACT
The antitumor activity of polyacrylates of the noble metals containing argentum (argacryl), aurum (auracryl) and platinum (platacryl) has been studied using experimental murine solid tumor models (Lewis lung carcinoma and Acatol adenocarcinoma). It has been found that polyacrylates of the noble metals are capable of inhibiting tumor development by 50-90% compared to control. Auracryl that inhibites the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 80 and 90%, respectively, compared to control is the most efficient among the tested compounds and can be recommended for the further profound preclinical studies.
Subject(s)
Acrylic Resins/pharmacology , Adenocarcinoma/drug therapy , Antineoplastic Agents/pharmacology , Carcinoma, Lewis Lung/drug therapy , Gold/pharmacology , Platinum/pharmacology , Silver/pharmacology , Acrylic Resins/chemistry , Adenocarcinoma/metabolism , Adenocarcinoma/pathology , Animals , Antineoplastic Agents/chemistry , Carcinoma, Lewis Lung/metabolism , Carcinoma, Lewis Lung/pathology , Drug Screening Assays, Antitumor , Gold/chemistry , Mice , Mice, Inbred BALB C , Platinum/chemistry , Silver/chemistrySubject(s)
Alanine Transaminase/blood , Alcohol Dehydrogenase/metabolism , Alcoholic Intoxication/drug therapy , Alcoholic Intoxication/metabolism , Antidotes/administration & dosage , Ethanol/poisoning , Zinc Compounds/administration & dosage , Alanine Transaminase/drug effects , Alcohol Dehydrogenase/drug effects , Alcoholic Intoxication/etiology , Animals , Animals, Outbred Strains , Antidotes/chemical synthesis , Behavior, Animal/drug effects , Enzyme Activation/drug effects , Rats , Treatment Outcome , Zinc Compounds/chemical synthesisSubject(s)
Monocytes/enzymology , Phenoxyacetates/pharmacology , Phospholipase A2 Inhibitors , Phospholipases A2/biosynthesis , Quaternary Ammonium Compounds/pharmacology , Animals , Atherosclerosis/blood , Atherosclerosis/drug therapy , Atherosclerosis/enzymology , Cholesterol/blood , Disease Models, Animal , Injections, Intramuscular , Lipoproteins/blood , Monocytes/drug effects , Phospholipases A2/metabolism , Rabbits , Triglycerides/bloodSubject(s)
Coordination Complexes/pharmacology , Ethanolamines/chemistry , Phenoxyacetates/pharmacology , Tryptophan-tRNA Ligase/biosynthesis , Zinc/chemistry , Animals , Aorta/drug effects , Aorta/enzymology , Disease Models, Animal , Enzyme Activation/drug effects , Hypercholesterolemia/drug therapy , Hypercholesterolemia/enzymology , Injections, Intramuscular , Phenoxyacetates/chemistry , Quaternary Ammonium Compounds/chemistry , Rabbits , Tryptophan-tRNA Ligase/metabolismSubject(s)
Atherosclerosis/complications , Enzyme Inhibitors/pharmacology , Liver Diseases/drug therapy , Liver/enzymology , Phenoxyacetates/pharmacology , Phospholipases A1/antagonists & inhibitors , Phospholipases A1/metabolism , Quaternary Ammonium Compounds/pharmacology , Animals , Atherosclerosis/metabolism , Cholesterol/metabolism , Disease Models, Animal , Lipoproteins, LDL/metabolism , Liver/drug effects , Liver Diseases/etiology , Liver Diseases/metabolism , Phospholipases A1/drug effects , Rabbits , Triglycerides/metabolismSubject(s)
Atherosclerosis/metabolism , Enzyme Activators/pharmacology , Lipase/drug effects , Lipase/metabolism , Phenoxyacetates/pharmacology , Quaternary Ammonium Compounds/pharmacology , Tunica Intima/enzymology , Animals , Aorta/chemistry , Aorta/enzymology , Atherosclerosis/chemically induced , Cholesterol/metabolism , Disease Models, Animal , Lipoproteins, LDL/metabolism , Rabbits , Triglycerides/metabolism , Tunica Intima/chemistrySubject(s)
Bridged Bicyclo Compounds, Heterocyclic/chemistry , Ethanolamines/chemistry , Germanium/chemistry , Organosilicon Compounds/chemistry , Antifungal Agents/pharmacology , Bacteria/drug effects , Bacteria/metabolism , Chemistry/methods , Disinfectants/pharmacology , Fungi/drug effects , Microbiology , Silicates/chemistry , Water/chemistrySubject(s)
Atherosclerosis/drug therapy , Atherosclerosis/metabolism , Blood Platelets/enzymology , Monocytes/enzymology , Phenoxyacetates/pharmacology , Quaternary Ammonium Compounds/pharmacology , Sterol Esterase/metabolism , Animals , Blood Coagulation/drug effects , Blood Platelets/drug effects , Disease Models, Animal , Lipid Metabolism/drug effects , Monocytes/drug effects , Rabbits , Sterol Esterase/drug effectsSubject(s)
Acrylic Resins/pharmacology , Anti-Infective Agents/pharmacology , Hemostatics/pharmacology , Acrylic Resins/chemistry , Animals , Hemostasis/drug effects , Humans , In Vitro Techniques , Metals/chemistry , Metals/pharmacology , Microbial Sensitivity Tests , Rabbits , Salts/chemistry , Salts/pharmacologySubject(s)
Antioxidants/pharmacology , Phenoxyacetates/pharmacology , Platelet Aggregation Inhibitors/pharmacology , Quaternary Ammonium Compounds/pharmacology , Antioxidants/chemistry , Blood Platelets/drug effects , Blood Platelets/metabolism , Humans , In Vitro Techniques , Lipid Peroxidation/drug effects , Phenoxyacetates/chemistry , Platelet Aggregation/drug effects , Platelet Aggregation Inhibitors/chemistry , Quaternary Ammonium Compounds/chemistrySubject(s)
Acetates/pharmacology , Atherosclerosis/drug therapy , Ethanolamines/pharmacology , Animals , Aorta/drug effects , Aorta/pathology , Aorta, Thoracic/pathology , Atherosclerosis/physiopathology , Body Weight , Cholesterol/metabolism , Drug Combinations , Drug Evaluation, Preclinical , Lipids/chemistry , Lipoproteins, LDL/chemistry , Liver/drug effects , Rabbits , Temperature , Time Factors , Triglycerides/metabolismSubject(s)
Microwaves/adverse effects , Quaternary Ammonium Compounds/pharmacology , Radiation Injuries, Experimental/prevention & control , Animals , Behavior, Animal/drug effects , Behavior, Animal/radiation effects , Brain/drug effects , Brain/metabolism , Brain/radiation effects , Exploratory Behavior/drug effects , Exploratory Behavior/radiation effects , Hot Temperature/adverse effects , Instinct , Male , Motor Activity/drug effects , Motor Activity/radiation effects , Quaternary Ammonium Compounds/administration & dosage , Quaternary Ammonium Compounds/therapeutic use , Radiation Dosage , Radiation Injuries, Experimental/blood , Radiation Injuries, Experimental/metabolism , Radiation Injuries, Experimental/mortality , Radiation-Protective Agents/administration & dosage , Radiation-Protective Agents/therapeutic use , Rats , Rats, Inbred Strains , Reflex/drug effects , Reflex/radiation effects , Thiobarbituric Acid Reactive Substances/metabolismSubject(s)
Acrylates/pharmacology , Polycarboxylate Cement/pharmacology , Acrylates/chemistry , Acrylates/therapeutic use , Animals , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Burns/drug therapy , Female , Homeostasis/drug effects , Male , Mice , Microbial Viability/drug effects , Polycarboxylate Cement/chemistry , Polycarboxylate Cement/therapeutic use , Rabbits , Toxicity Tests, Acute , Wound Healing/drug effectsABSTRACT
The screening of 13 original compounds from the group of derivatives of arylheteroalkanecarboxylic acid on immunity were performed. The compounds exhibit strong myelostimulating/myelosuppressive property, increased or decreased influence on the: PFC (IgM and IgG), DTH at the sheep erythrocytes in CBF1 in vivo. In contrast, in vitro the compounds had no effect or inhibited the spontaneous, ConA or PWM induced proliferation of the splenocytes from normal mice. The problems of the universal methods of the screening of immunoactive properties of compounds are discussed.
Subject(s)
Antibody Formation/drug effects , Carboxylic Acids/pharmacology , Immune Tolerance/drug effects , Animals , Antibody Formation/immunology , Carboxylic Acids/immunology , Cell Proliferation/drug effects , Cells, Cultured , Female , Immunoglobulin G/immunology , Immunoglobulin M/immunology , Male , Mice , Sheep , Spleen/cytology , Spleen/immunologyABSTRACT
The aim of this work was to study the effect of 1-chloromethyisilatranum on the processes of reparative bone regeneration in experimentally induced aseptic femoral head necrosis. Aseptic femoral head necrosis was modeled in 4 Chinchilla rabbits by destruction of spongy substance of femoral neck and cutting of ligamentum teres of its head. Rabbits of the experimental group were injected with 0.4 ml of 1% solution of 1-chloromethylsilatranum on postoperational days 5, 10, 15 and 20 into the damaged femoral head and close to the damaged joint. Animal were sacrificed by air embolism 5 weeks from the start of an experiment. Necrotic and repair processes in hip joints from damaged and intact sides were assessed radiologically and histologically prior to sacrifice. In rabbits of both control and experimental groups extensive aseptic necrosis of hip joints was found. The osseous tissue of damaged hip joints of experimental animals contained the chains of osteoblasts actively producing new bone matrix. Foci of bone regeneration were found both in the deep and peripheral regions of the epiphysis, which is indicative of active processes of bone repair. The results obtained suggest that administration of organic-silicon drug 1-chloromethylsilatranum stimulates (optimizes) the processes of repair osteogenesis following aseptic femoral head necrosis in experimental animals. Application of this preparation appears to be very promising.