[Structural changes in the endothelium of the major arteries under conditions of longitudinal stretching in vivo (based on scanning electron microscopic data)]. / Izmenenie struktury éndoteliia magistral'nykh arterii v usloviiakh prodol'nogo rastiazheniia in vivo (po dannym skaniruiushchei élektronnoi mikroskopii).

The method of scanning electron microscopy was used for studying three-dimensional organization of the endothelium of major vessels under conditions of distraction in vivo. The distraction resulted in an enlargement of the spaces between endotheliocytes without formation of considerable areas of deendothelialized surface. The main mechanism of induction of flattening and division of endotheliocytes in the zone of distraction seems to be the elimination of the contact inhibition resulting from a mechanical distraction.

[Changes in the spatial organization and structure of the smooth-muscle cells of the tunica media of the major arteries during lengthwise stretching in situ]. / Izmenenie prostranstvennoi organizatsii i struktury gladkomyshechnykh kletok srednei obolochki magistral'nykh arterii v usloviiakh prodol'nogo rastiazheniia in situ.

It has been shown that in vivo stretching of the arterial wall leads to the loss of cell-cell contacts between medial smooth muscle cells (SMC), and to the change in the cell cooperation type. It is accompanied by the increase in SMC proliferative activity, and by changes in their shape and phenotype, from the contractile to the synthetic one. The increase in the number of extracellular connective tissue structures occurs in the intercellular space.

[Changes in the orientation of the smooth-muscle cells of the tunica media from major arteries under constant lengthwise stretching in situ]. / Izmenenie orientatsii gladkomyshechnykh kletok srednei obolochki magistral'nykh arterii v usloviiakh postoiannogo prodol'nogo rastiazheniia in situ.

It has been shown that changes in the orientation of arterial smooth muscle cells during a constant longitudinal stretching of the artery in vivo are not similar in different sections of the stretching zone. Cells in the proximal and distal sections keep their orientation but this orientation differs from that of smooth muscle cells in the control arteries. Cells in the central part of the stretching region lose their definite orientation to settle randomly.