Lactation inhibition by a single injection of a new depot-bromocriptine.

Recently, long-acting injectable forms of bromocriptine have become available for the prevention of lactation. The first developed depot-form was very effective, but had the disadvantage of a slowly metabolized carrier. we investigated the pharmacokinetics, efficacy, tolerance and safety of 40 and 50 mg of a new rapidly eliminated depot-form in 61 postpartum women. Bromocriptine rapidly increased after injection and prolactin was effectively suppressed during the study-period of 60 days. Overall efficacy was very good or good in 98% and no rebound lactation occurred. Sixteen women experienced side effects. Tolerance at the injection site was good and safety tests did not show abnormalities. There were no differences between the two dosages. We conclude that this new depot-bromocriptine is a safe, well tolerated and effective drug in the suppression of prolactin and the prevention of post-partum lactation.

The value of ultrasonic placental grading: no correlation with intrauterine growth retardation or with maternal smoking.

In a prospective study the usefulness of placental grading in detecting IUGR has been evaluated. Those who were echoscopically examined within one week before delivery were taken into the study (n = 137). Changes in placental tissue increased clearly as pregnancy progressed and in 42% (57/137) the placentae reached Grade III. Increasing placental grading is associated with normal maturation of the placenta. Post partum examination of the placenta correlated well with the echoscopic picture (accuracy = 80.5%). No relationship was found in an unselected group between Grade III and IUGR at term. When a Grade III placenta was first seen before 36 weeks, in three out of five cases a growth retarded neonate was born. The effects of maternal smoking habits during pregnancy on birth weight and placenta were examined. There were no significant differences in mean placental weight, placental ratio and placental grading as the amount of cigarettes increased. The mean birth weight and birth weight percentile decreased significantly when the mother smoked more than 10 cigarettes per day.

PIP: In a prospective study, the usefulness of placental grading in detecting IUGR has been evaluated. Those who were echoscopically examined within 1 week before delivery were added to the study (n=137). Changes in placental tissue increased clearly as pregnancy progressed and in 42%, (57/137), the placentae reached grade III. Increasing placental grading is associated with normal maturation of the placenta. Postpartum examination of the placenta correlated well with the echoscopic picture (accuracy=80.5%). No relationship was found in an unselected group between grade III and IUGR at term. When a grade III placenta was 1st seen prior to 36 weeks, a growth-retarded infant was born in 3 of 5 cases. The effects of the maternal smoking during pregnancy on birthweight and placenta were examined. There were no significant differences in mean placental weight, placental ratio, and placental grading, as the number of cigarettes increased. The mean birthweight and birthweight percentile decreased significantly when the mother smoked more than 10 cigarettes/day. (author's modified)